Document Detail


Effects of rifampicin on pharmacokinetics of isoniazid and its metabolite acetylhydrazine in rats.
MedLine Citation:
PMID:  1302435     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
After i.v. and i.p. injections of isoniazid (Iso) 40 mg.kg-1 to male Wistar rats, the plasma levels of Iso, acetylisoniazid (AcIso), and acetylhydrazine (AcHz) were determined by spectrophotometric method and gas chromatography. The results suggested that the pharmacokinetic behavior of Iso in rats belonged to a 2-compartment model. The plasma levels of AcHz in rifampicin (Rif 30 mg.kg-1)-pretreated rats were lowered vs the control (P < 0.05 or < 0.01). The T1/2 of AcHz was shortened by Rif (control group 3.3 h, Rif-pretreated group 1.4 h) after i.v. injection of AcHz 10 mg.kg-1 to rats and the results showed that AcHz was converted to its active metabolites quickly by increasing the oxidative elimination rate of AcHz, which is related to the higher incidence of liver necrosis caused by Iso and Rif in combination.
Authors:
R L Zhang; Z Y Wang; D Li; W B Cheng
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Zhongguo yao li xue bao = Acta pharmacologica Sinica     Volume:  13     ISSN:  0253-9756     ISO Abbreviation:  Zhongguo Yao Li Xue Bao     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1993-06-09     Completed Date:  1993-06-09     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8100330     Medline TA:  Zhongguo Yao Li Xue Bao     Country:  CHINA    
Other Details:
Languages:  eng     Pagination:  494-6     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, School of Pharmacy, Shanghai Medical University, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Drug Interactions
Drug-Induced Liver Injury / etiology
Hydrazines / blood,  pharmacology
Isoniazid / analogs & derivatives*,  blood,  pharmacokinetics*
Male
Rats
Rats, Wistar
Rifampin / pharmacology*
Chemical
Reg. No./Substance:
0/Hydrazines; 1068-57-1/acetylhydrazine; 1078-38-2/(N)1-acetylisoniazid; 13292-46-1/Rifampin; 54-85-3/Isoniazid

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