Document Detail


Effects of ribose on exercise-induced ischaemia in stable coronary artery disease.
MedLine Citation:
PMID:  1354276     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is no established treatment specifically aimed at protecting or restoring cardiac energy metabolism, which is greatly impaired by ischaemia. Even after reperfusion, myocardial content of ATP remains low for more than 72 h. Long-term post-ischaemic dysfunction and irreversibility of ischaemic damage have been associated with low ATP content. Evidence that the pentose sugar ribose stimulates ATP synthesis and improves cardiac function led us to test the possibility that ribose increases tolerance to myocardial ischaemia in patients with coronary artery disease (CAD). 20 men with documented severe CAD underwent two symptom-limited treadmill exercise tests on 2 consecutive days; we postulated that the ischaemia induced might bring about changes in ATP metabolism lasting for several days. Patients whose baseline tests showed reproducibility were randomly allocated 3 days of treatment with placebo or ribose 60 g daily in four doses by mouth. Exercise testing was repeated after treatment on day 5. At that time mean (95% confidence interval) treadmill walking time until 1 mm ST-segment depression was significantly greater in the ribose than in the placebo group (276 [220-331] vs 223 [188-259] s; p = 0.002). The groups did not differ significantly in time to moderate angina. In the ribose-treated group the changes from baseline to day 5 in both time to ST depression and time to moderate angina were significant (p less than 0.005), but these changes were not significant in the placebo group. In patients with CAD, administration of ribose by mouth for 3 days improved the heart's tolerance to ischaemia. The presumed effects on cardiac energy metabolism offer new possibilities for adjunctive medical treatment of myocardial ischaemia.
Authors:
W Pliml; T von Arnim; A Stäblein; H Hofmann; H G Zimmer; E Erdmann
Related Documents :
8659246 - Beta-endorphin and propiomelanocortin-correlates peptides response in suspected and con...
3680356 - Ingrowing toenails: is there a nail abnormality? a prospective study.
3549086 - Current review of exercise testing: application and interpretation.
7942546 - Prognostic implications of normal exercise tomographic thallium images in patients with...
8455256 - Aortic occlusion and lower extremity exercise induced stress urinary incontinence.
17470336 - Prevalence and management of chronotropic incompetence in heart failure.
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lancet     Volume:  340     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-09-17     Completed Date:  1992-09-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  507-10     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, Medizinische Klinik I, Klinikum Grosshadern, Germany.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aged
Coronary Disease / physiopathology,  prevention & control*
Electrocardiography
Exercise Test
Humans
Male
Middle Aged
Ribose / therapeutic use*
Chemical
Reg. No./Substance:
50-69-1/Ribose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Randomised controlled trial of adjuvant chemotherapy by portal-vein perfusion after curative resecti...
Next Document:  Antibodies to silicone elastomers and reactions to ventriculoperitoneal shunts.