| Effects of retrovenous myocardial drug delivery after coronary artery occlusion in sheep. | |
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MedLine Citation:
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PMID: 2252657 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Retrovenous (RV) myocardial delivery of blood and drugs into the coronary sinus (CS) through a 3 lumen balloon catheter was evaluated in sheep (no coronary collaterals) for protection from ventricular fibrillation (VF) during coronary artery occlusion. The balloon was asynchronously inflated (CS occlusion) for 5 sec and then deflated for 5 sec with 1 cc/sec of flow. The left anterior descending coronary artery was occluded with inflation of a percutaneous transluminal coronary angiography balloon and therapy started immediately. In a control group (no therapy, n = 4) all developed VF by 30 min after coronary artery occlusion. The drugs lidocaine (L), esmolol (E), adenosine (A), and deferoxamine (D) were evaluated for effects on eliminating developing VF with intravenous (i.v.) administration compared with RV administration with venous blood (VB) or arterial blood (AB). The percent survival after CA occlusion (no VF) was: L i.v., 0%; L RV with VB, 43%; L RV with AB, 17%; E i.v., 50%; E RV with VB, 70%; A. i.v., 29%; A RV with VB, 88%; D i.v., 17%; and D RV with AB, 80%. There was a trend toward lower myocardial necrosis (seen by tetrazolium stain and/or light microscopy) in the RV survivors (especially with VB) compared with the group i.v. survivors. These data suggest that RV antiarrhythmic drug delivery is a feasible alternative to i.v. administration during CA occlusion. |
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Authors:
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T A Davy; J L Orth; J L Peters |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: ASAIO transactions / American Society for Artificial Internal Organs Volume: 36 ISSN: 0889-7190 ISO Abbreviation: ASAIO Trans Publication Date: 1990 Jul-Sep |
Date Detail:
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Created Date: 1991-01-22 Completed Date: 1991-01-22 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8611947 Medline TA: ASAIO Trans Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: M203-6 Citation Subset: IM |
Affiliation:
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Utah Biomedical Testing Laboratories, Inc., Salt Lake City. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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administration & dosage Animals Anti-Arrhythmia Agents / administration & dosage* Coronary Circulation / drug effects Deferoxamine / administration & dosage Electrocardiography / drug effects* Heart Catheterization / instrumentation Heart Conduction System / drug effects Lidocaine / administration & dosage Myocardial Infarction / drug therapy* Propanolamines / administration & dosage Sheep Ventricular Fibrillation / drug therapy* |
| Grant Support | |
ID/Acronym/Agency:
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HL31215-01A1/HL/NHLBI NIH HHS; HL34283-02/HL/NHLBI NIH HHS; HL36504-03/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 0/Propanolamines; 137-58-6/Lidocaine; 58-61-7/Adenosine; 70-51-9/Deferoxamine; 84057-94-3/esmolol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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