Document Detail

Effects of retinoids on type IV collagenolytic activity in melanoma cells.
MedLine Citation:
PMID:  2430409     Owner:  NLM     Status:  MEDLINE    
The effects of retinol, all-trans-retinoic acid, isotretinoin and etretinate on the activity of basement membrane collagen degrading enzyme was studied in melanoma cells. The results indicated that retinoids at concentrations of up to 10(-6) M did not significantly affect type IV collagenolytic activity in these cells in vitro. Since type IV collagenolytic enzyme may be involved in the metastatic potential of tumour cells, it appears that retinoids do not affect the metastatic potential of melanoma cells by affecting type IV collagenolytic activity.
A Oikarinen; T Salo
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  66     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  1986  
Date Detail:
Created Date:  1986-12-02     Completed Date:  1986-12-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  346-8     Citation Subset:  IM    
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MeSH Terms
Cells, Cultured
Etretinate / pharmacology
Melanoma / enzymology*
Microbial Collagenase / analysis,  metabolism*
Neoplasm Metastasis / enzymology
Retinoids / pharmacology*
Skin Neoplasms / enzymology*
Tretinoin / pharmacology
Vitamin A / pharmacology
Reg. No./Substance:
0/Retinoids; 11103-57-4/Vitamin A; 302-79-4/Tretinoin; 4759-48-2/Isotretinoin; 54350-48-0/Etretinate; EC Collagenase

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