Document Detail


Effects of retinoids and juvenoids on moult and on phenoloxidase activity in the blood-sucking insect Rhodnius prolixus.
MedLine Citation:
PMID:  17686447     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Retinoic acid and insect juvenile hormone (JH) are structurally related terpenoids which are widespread in nature and are involved in many biological events such as morphogenesis, embryogenesis and cellular differentiation. Here, we investigated the effects of the retinoids 9-cis retinoic acid (9cisRA), all trans retinol (atROH), all trans retinoic acid (atRA) and the juvenoids methoprene (Met) and JH injection on moult and on phenoloxidase activity in the blood-sucking insect Rhodnius prolixus. Overall, we observed that injection of retinoids or juvenoids (120 pmols) in the hemocoel of 4th instar nymphs reduced the percentage of insects which appeared normal in morphology upon moult. Noteworthy, insects exposed to 9cisRA or JH underwent profound morphological changes upon moult, generating abnormal 5th instar nymphs and also markedly increased the death of insects during the moulting process. In addition, reduction in the percentage of insects that moult without any morphological alteration, induced by retinoids or juvenoids treatment, was negatively correlated with insects that both display abnormal moult and those that die during moult. Hemolymphatic phenoloxidase activity in adult male insects injected with 9cisRA, Met and JH were significantly reduced after a bacterial challenge. Together, these results indicate that not only juvenoids but also retinoids play an important role on morphogenesis and on immune response in R. prolixus, suggesting that the molecular mechanisms involved in these events recognize the terpenoid backbone as an important structural determinant in insects.
Authors:
Angelica Nakamura; Renata Stiebler; Marcelo R Fantappié; Eliane Fialho; Hatisaburo Masuda; Marcus F Oliveira
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-07-01
Journal Detail:
Title:  Acta tropica     Volume:  103     ISSN:  0001-706X     ISO Abbreviation:  Acta Trop.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-28     Completed Date:  2007-11-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370374     Medline TA:  Acta Trop     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  222-30     Citation Subset:  IM    
Affiliation:
Instituto de Bioquímica Médica, Programa de Biologia Molecular e Biotecnologia, Universidade Federal do Rio de Janeiro, Cidade Universitária, Rio de Janeiro, RJ 21941-590, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Animals
Juvenile Hormones / chemistry,  pharmacology*
Methoprene / chemistry,  pharmacology*
Molting / drug effects*
Monophenol Monooxygenase / drug effects*,  metabolism
Retinoids / chemistry,  pharmacology*
Rhodnius / drug effects*,  enzymology,  growth & development
Chemical
Reg. No./Substance:
0/Juvenile Hormones; 0/Retinoids; 40596-69-8/Methoprene; EC 1.14.18.1/Monophenol Monooxygenase

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