Document Detail

Effects of retinoic acid on ischemic brain injury-induced neurogenesis.
MedLine Citation:
PMID:  17603284     Owner:  NLM     Status:  MEDLINE    
Neurogenesis can be induced by pathological conditions such as cerebral ischemia. However the molecular mechanisms or modulating reagents of the reactive neurogenesis after the cerebral ischemia are poorly characterized. Retinoic acid (RA) has been shown to increase neurogenesis by enhancing the proliferation and neuronal differentiation of forebrain neuroblasts. Here, we examined whether RA can modulate the reactive neurogenesis after the cerebral ischemia. In contrast to our expectation, RA treatment decreased the reactive neurogenesis in subventricular zone (SVZ), subgranular zone (SGZ) and penumbral region. Furthermore, RA treatment also decreased the angiogenesis and gliosis in penumbral region.
Dae-Soo Jung; Sun-Yong Baek; Kyu-Hyun Park; Young-In Chung; Hak-Jin Kim; Chi-Dae Kim; Min-Kyoung Cho; Myoung-Eun Han; Kyung-Pil Park; Bong-Seon Kim; Jae-Bong Kim; Sae-Ock Oh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental & molecular medicine     Volume:  39     ISSN:  1226-3613     ISO Abbreviation:  Exp. Mol. Med.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-07-02     Completed Date:  2007-09-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9607880     Medline TA:  Exp Mol Med     Country:  Korea (South)    
Other Details:
Languages:  eng     Pagination:  304-15     Citation Subset:  IM    
Department of Neurology, School of Medicine, Pusan National University, Busan 602-739, Korea.
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MeSH Terms
Brain / blood supply
Cell Differentiation
Cell Proliferation
Ischemic Attack, Transient / metabolism,  pathology*
Neovascularization, Pathologic
Neuroglia / pathology,  physiology
Neurons / pathology,  physiology*
Rats, Sprague-Dawley
Tretinoin / pharmacology*,  physiology
Reg. No./Substance:

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