| Effects of retinoic acid on ischemic brain injury-induced neurogenesis. | |
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MedLine Citation:
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PMID: 17603284 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neurogenesis can be induced by pathological conditions such as cerebral ischemia. However the molecular mechanisms or modulating reagents of the reactive neurogenesis after the cerebral ischemia are poorly characterized. Retinoic acid (RA) has been shown to increase neurogenesis by enhancing the proliferation and neuronal differentiation of forebrain neuroblasts. Here, we examined whether RA can modulate the reactive neurogenesis after the cerebral ischemia. In contrast to our expectation, RA treatment decreased the reactive neurogenesis in subventricular zone (SVZ), subgranular zone (SGZ) and penumbral region. Furthermore, RA treatment also decreased the angiogenesis and gliosis in penumbral region. |
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Authors:
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Dae-Soo Jung; Sun-Yong Baek; Kyu-Hyun Park; Young-In Chung; Hak-Jin Kim; Chi-Dae Kim; Min-Kyoung Cho; Myoung-Eun Han; Kyung-Pil Park; Bong-Seon Kim; Jae-Bong Kim; Sae-Ock Oh |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Experimental & molecular medicine Volume: 39 ISSN: 1226-3613 ISO Abbreviation: Exp. Mol. Med. Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-07-02 Completed Date: 2007-09-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9607880 Medline TA: Exp Mol Med Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 304-15 Citation Subset: IM |
Affiliation:
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Department of Neurology, School of Medicine, Pusan National University, Busan 602-739, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / blood supply Cell Differentiation Cell Proliferation Ischemic Attack, Transient / metabolism, pathology* Male Neovascularization, Pathologic Neuroglia / pathology, physiology Neurons / pathology, physiology* Rats Rats, Sprague-Dawley Tretinoin / pharmacology*, physiology |
| Chemical | |
Reg. No./Substance:
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302-79-4/Tretinoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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