Document Detail

Effects of retinoic acid on chick tail bud development.
MedLine Citation:
PMID:  2014484     Owner:  NLM     Status:  MEDLINE    
The present study describes the teratogenic effects of retinoic acid (RA) on the development of the chick tail bud. Chick embryos were recovered 48 hours after treatment at HH stages 11 to 16 with various dosages of RA by subblastodermal injection. At the gross level, RA treatment resulted in varying degrees of caudal regression, scoliosis, limb malformations, and open posterior neuropores among the survivors. Histological examination of tail buds from treated embryos revealed defects which included total dysplasia of caudal structures, the presence of accessory neural tube and notochord tissue, and abnormal fusions of the notochord to the neural tube and tailgut. The incidence, severity, and location of the defects were dependent on the dose of the teratogen, and the stage of development at the time of treatment. The defects resembled those induced in previous studies by treatment with sialic acid binding lectins such as wheat germ agglutinin and limulus polyphemus lectin (Griffith and Wiley, '90b).
C M Griffith; M J Wiley
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Teratology     Volume:  43     ISSN:  0040-3709     ISO Abbreviation:  Teratology     Publication Date:  1991 Mar 
Date Detail:
Created Date:  1991-05-15     Completed Date:  1991-05-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0153257     Medline TA:  Teratology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  217-24     Citation Subset:  IM    
Department of Anatomy, University of Toronto, Ontario, Canada.
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MeSH Terms
Abnormalities, Drug-Induced / embryology*
Chick Embryo
Dose-Response Relationship, Drug
Limb Deformities, Congenital
Neural Tube Defects / chemically induced,  embryology
Notochord / abnormalities
Tail / abnormalities*
Tretinoin / administration & dosage,  toxicity*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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