| Effects of resveratrol on the amelioration of insulin resistance in KKA(y) mice. | |
| | |
MedLine Citation:
|
PMID: 22309033 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Resveratrol (Res) has attracted great interest regarding its effects related to metabolic syndrome, especially for lipid metabolic disorder or insulin resistance; however, the underlying mechanisms remain elusive. To explore the effects of Res on insulin sensitivity and the underlying mechanism, insulin-resistant KKA(y) mice were treated with 2 and 4 g/kg diets of Res for 12 weeks. After the treatment, blood glucose, serum insulin, glucose tolerance, and insulin tolerance, as well as other indices such as adiponectin mRNA in epididymal adipose tissues, silent information regulator 1 (Sirt1), AMP-activated protein kinase (AMPK), insulin receptor substrate 1 (IRS1), and phosphorylated protein kinase B (PKB/AKT) proteins in liver and soleus muscles, were investigated. The results indicate that Res intervention reduces blood glucose and serum insulin levels, improves insulin and glucose tolerance, increases serum adiponectin and adiponectin mRNA levels in epididymal adipose tissues, and more importantly, elevates Sirt1, p-AMPK, p-IRS1, and p-AKT levels in liver and soleus muscles. In conclusion, Res could improve insulin sensitivity and ameliorate insulin resistance in KKA(y) mice, which may be associated with the upregulation of Sirt1 protein in liver and soleus muscles and consequent AMPK activation, as well as insulin-signaling related proteins. |
| | |
Authors:
|
Sifan Chen; Jinghua Li; Zili Zhang; Wenxue Li; Yanshuang Sun; Quanxin Zhang; Xiang Feng; Wei Zhu |
Related Documents
:
|
22572803 - Early life treatment with vancomycin propagates akkermansia muciniphila and reduces dia... 8732493 - Acute hyperinsulinaemia decreases cholesterol synthesis less in subjects with non-insul... 14304253 - Association of acute local reactions to insulin with an insulin-binding gamma i m antib... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-2-6 |
Journal Detail:
|
Title: Canadian journal of physiology and pharmacology Volume: - ISSN: 1205-7541 ISO Abbreviation: - Publication Date: 2012 Feb |
Date Detail:
|
Created Date: 2012-2-7 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372712 Medline TA: Can J Physiol Pharmacol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
a Guangzhou Center for Disease Control and Prevention, Guangzhou, Guangdong, P.R. China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Heterogeneous Reactions of Epoxides in Acidic Media.
Next Document: Transjugular intrahepatic portosystemic shunt following liver transplantation: can outcomes be predi...