Document Detail

Effects of resistive loading on the pattern of breathing.
MedLine Citation:
PMID:  9832235     Owner:  NLM     Status:  MEDLINE    
In order to determine changes in breathing patterns brought about by resistive loading, ventilation was recorded in 11 healthy subjects with four linear resistances (3.57, 5.75, 8.76 and 13.13 cmH2O L(-1) sec) added in a random order throughout the entire breath. At steady state, a breath-by-breath analysis of airflow was used to quantify the pattern of breathing in terms of respiratory variables: TI, TE, Tt, VT, VT/TI, TI/Tt, and by taking TI, TE, VT all together (TRIAD) and also the shape of the entire airflow profile quantified by harmonic analysis (ASTER). Group analysis using ANOVA showed significant changes in all variables. There were increasing changes with increasing loads in all variables, the smallest changes being in TI/Tt. Within to between-individual comparisons between two loads showed that only TI/Tt and the ASTER were more similar within than between-individuals for all comparisons. It was concluded that at steady state mechanisms of load compensation come into play inducing changes in the pattern of breathing proportional to the loads while maintaining some of the individual characteristics.
P Calabrese; T P Dinh; A Eberhard; J P Bachy; G Benchetrit
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Respiration physiology     Volume:  113     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1998 Aug 
Date Detail:
Created Date:  1999-03-03     Completed Date:  1999-03-03     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  167-79     Citation Subset:  IM    
Physiologie Respiratoire, Expérimentale, Théorique et Appliquée, Faculté de Médecine de Grenoble, La Tronche, France.
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MeSH Terms
Adaptation, Physiological / physiology
Air Pressure
Airway Resistance / physiology*
Carbon Dioxide / administration & dosage,  pharmacology
Middle Aged
Reference Values
Respiratory Mechanics / physiology*
Reg. No./Substance:
124-38-9/Carbon Dioxide

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