| Effects of resistance training on insulin-like growth factor and its binding proteins in men and women aged 60 to 85. | |
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MedLine Citation:
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PMID: 12028176 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: We have reported that resistance training (RT) elevates insulin-like growth factor (IGF-I) in healthy young adults. Our goals were to determine whether RT produces a similar effect in the healthy older persons and to determine the effects of low- versus high-intensity RT on hormonal status. SETTING: Center for Exercise Science, University of Florida, Gainesville. PARTICIPANTS: Sixty-two men and women (mean age = 68.1). INTERVENTION: A 6-month, 3-day/week program of low-intensity RT (LEX), high-intensity RT (HEX), or no exercise (CON). MEASUREMENTS: Before and after training, blood was drawn for hormone analysis. IGF-I, IGF binding protein-1 (IGFBP-1), and IGFBP-3 were measured at rest. Testosterone and cortisol were measured at rest and immediately after exercise. RESULTS: RT caused significant increases in 1-repetition maximum (1RM) strength and peak oxygen consumption (V02peak), which we have reported separately. Currently, we report that RT had no effect on the resting serum concentrations of IGF-I, IGFBP-1, IGFBP-3, testosterone, or cortisol. Acute resistance exercise caused no change in circulating testosterone in men or women but did cause a significant elevation of cortisol in the HEX group. This increase in cortisol was blunted as a result of training. CONCLUSIONS: We conclude that the increases in strength and endurance caused by RT were not mediated by increases in circulating IGF-I, IGFBPs, or testosterone. |
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Authors:
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Stephen E Borst; Kevin R Vincent; David T Lowenthal; Randy W Braith |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of the American Geriatrics Society Volume: 50 ISSN: 0002-8614 ISO Abbreviation: J Am Geriatr Soc Publication Date: 2002 May |
Date Detail:
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Created Date: 2002-05-24 Completed Date: 2002-06-12 Revised Date: 2008-03-10 |
Medline Journal Info:
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Nlm Unique ID: 7503062 Medline TA: J Am Geriatr Soc Country: United States |
Other Details:
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Languages: eng Pagination: 884-8 Citation Subset: IM |
Affiliation:
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Department of Exercise and Sport Sciences, University of Florida, Gainesville, Florida, USA. sborst@pharmacology.ufl.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Aged Aged, 80 and over Exercise / physiology* Female Humans Hydrocortisone / blood Insulin-Like Growth Factor Binding Protein 1 / blood* Insulin-Like Growth Factor Binding Protein 3 / blood* Male Middle Aged Reference Values Sex Factors Somatomedins / analysis* Testosterone / blood Time Factors Weight Lifting / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Insulin-Like Growth Factor Binding Protein 1; 0/Insulin-Like Growth Factor Binding Protein 3; 0/Somatomedins; 50-23-7/Hydrocortisone; 58-22-0/Testosterone |
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