Document Detail

Effects of residual oil fly ash (ROFA) in mice with chronic allergic pulmonary inflammation.
MedLine Citation:
PMID:  18477768     Owner:  NLM     Status:  MEDLINE    
Exposure to particulate matter (PM) air pollution is associated with increased asthma morbidity. Residual oil flash ash (ROFA) is rich in water-soluble transition metals, which are involved in the pathological effects of PM. The objective of this study was to investigate the effects of intranasal administration of ROFA on pulmonary inflammation, pulmonary responsiveness, and excess mucus production in a mouse model of chronic pulmonary allergic inflammation. BALB/c mice received intraperitoneal injections of ovalbumin (OVA) solution (days 1 and 14). OVA challenges were performed on days 22, 24, 26, and 28. After the challenge, mice were intranasally instilled with ROFA. After forty-eight hours, pulmonary responsiveness was performed. Mice were sacrificed, and lungs were removed for morphometric analysis. OVA-exposed mice presented eosinophilia in the bronchovascular space (p < .001), increased pulmonary responsiveness (p < .001), and epithelial remodeling (p = .003). ROFA instillation increased pulmonary responsiveness (p = .004) and decreased the area of ciliated cells in the airway epithelium (p = .006). The combined ROFA instillation and OVA exposure induced a further increase in values of pulmonary responsiveness (p = .043) and a decrease in the number of ciliated cells in the airway epithelium (p = .017). PM exposure results in pulmonary effects that are more intense in mice with chronic allergic pulmonary inflammation.
Fernanda M Arantes-Costa; Fernanda D T Q S Lopes; Alessandra C Toledo; Pedro A Magliarelli-Filho; Henrique T Moriya; Regiane Carvalho-Oliveira; Thais Mauad; Paulo H N Saldiva; Milton A Martins
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Publication Detail:
Type:  Journal Article     Date:  2008-05-13
Journal Detail:
Title:  Toxicologic pathology     Volume:  36     ISSN:  1533-1601     ISO Abbreviation:  Toxicol Pathol     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-08-14     Completed Date:  2008-10-16     Revised Date:  2012-01-05    
Medline Journal Info:
Nlm Unique ID:  7905907     Medline TA:  Toxicol Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  680-6     Citation Subset:  IM    
Department of Medicine, School of Medicine, University of São Paulo, Brazil.
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MeSH Terms
Air Pollutants / adverse effects*,  analysis,  chemistry
Carbon / toxicity*
Chronic Disease
Coal Ash
Disease Models, Animal
Hypersensitivity / immunology,  pathology,  physiopathology*
Inhalation Exposure / adverse effects*,  analysis
Mice, Inbred BALB C
Ovalbumin / immunology
Particle Size
Particulate Matter / toxicity*
Pneumonia / etiology*
Reg. No./Substance:
0/Air Pollutants; 0/Coal Ash; 0/Particulate Matter; 7440-44-0/Carbon; 9006-59-1/Ovalbumin

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