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Effects of repeated maternal oral exposure to low levels of trichlorfon on development and cytogenetic toxicity in 3-day mouse embryos.
MedLine Citation:
PMID:  21771630     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Trichlorfon is a widely used broad-spectrum agricultural insecticide. Few studies have evaluated the effects of trichlorfon on developing fetuses, especially at early stages of development after low-level maternal exposures. In this study, we evaluated the direct effects of trichlorfon on preimplantation mouse embryos after 30days of maternal exposure (2, 10 and 50mg/kg/day) via drinking water. On gestation day 3 (dg3), blastocysts were collected and evaluated for changes in gross morphology; cell number; the presence of interphase, metaphase, micronuclei (MN) cells and fragmented and pycnotic nuclei. Embryos in the 50mg/kg/day group had a significantly reduced mean cell number per embryo. Furthermore, there was a significant increase in the frequency of pycnotic nuclei and an absence of metaphase cells in the 50mg/kg/day treated group. None of the developmental endpoints evaluated were observed in the 2 and 10mg/kg/day trichlorfon-treated groups. A simultaneous decrease in the cell number and an increase in the frequencies of absent metaphases and pycnotic nuclei indicate that embryonic developmental deficits observed in the 50mg/kg/day exposure group were associated with cytotoxicity.
Authors:
Ying Tian; Shufang Zhou; Yu Gao; Yijun Zhou; Rong Shi; Wendy Heiger-Bernays; Yu Ding; Pei Wang; Song Han; Xiaoming Shen
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-13
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  -     ISSN:  1873-6351     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Ltd.
Affiliation:
Shanghai Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Children's Environmental Health, 200092 Shanghai, China; Department of Environmental Health, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China.
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