| Effects of repeated maternal oral exposure to low levels of trichlorfon on development and cytogenetic toxicity in 3-day mouse embryos. | |
| | |
MedLine Citation:
|
PMID: 21771630 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Trichlorfon is a widely used broad-spectrum agricultural insecticide. Few studies have evaluated the effects of trichlorfon on developing fetuses, especially at early stages of development after low-level maternal exposures. In this study, we evaluated the direct effects of trichlorfon on preimplantation mouse embryos after 30days of maternal exposure (2, 10 and 50mg/kg/day) via drinking water. On gestation day 3 (dg3), blastocysts were collected and evaluated for changes in gross morphology; cell number; the presence of interphase, metaphase, micronuclei (MN) cells and fragmented and pycnotic nuclei. Embryos in the 50mg/kg/day group had a significantly reduced mean cell number per embryo. Furthermore, there was a significant increase in the frequency of pycnotic nuclei and an absence of metaphase cells in the 50mg/kg/day treated group. None of the developmental endpoints evaluated were observed in the 2 and 10mg/kg/day trichlorfon-treated groups. A simultaneous decrease in the cell number and an increase in the frequencies of absent metaphases and pycnotic nuclei indicate that embryonic developmental deficits observed in the 50mg/kg/day exposure group were associated with cytotoxicity. |
| | |
Authors:
|
Ying Tian; Shufang Zhou; Yu Gao; Yijun Zhou; Rong Shi; Wendy Heiger-Bernays; Yu Ding; Pei Wang; Song Han; Xiaoming Shen |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-7-13 |
Journal Detail:
|
Title: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association Volume: - ISSN: 1873-6351 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
|
Created Date: 2011-7-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8207483 Medline TA: Food Chem Toxicol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011. Published by Elsevier Ltd. |
Affiliation:
|
Shanghai Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Children's Environmental Health, 200092 Shanghai, China; Department of Environmental Health, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Inhibitory effects of (-)-?-bisabolol on LPS-induced inflammatory response in RAW264.7 macrophages.
Next Document: The effects of vitamin A supplementation to rats during gestation and lactation upon redox parameter...