Document Detail

Effects of repeated MDMA administration on the motivation for palatable food and extinction of operant responding in mice.
MedLine Citation:
PMID:  20066403     Owner:  NLM     Status:  MEDLINE    
RATIONALE: Repeated administration of 3,4-methylenedioxymethamphetamine (MDMA) produces mainly dopaminergic neurotoxicity in mice. However, the consequences of this exposure on the behavioural responses related to natural reinforcing stimuli are still largely unknown.
OBJECTIVES: We examined whether repeated treatment with neurotoxic and non-neurotoxic doses of MDMA could exert acute and long-lasting effects on the motivation of mice to obtain a highly palatable food and on the extinction and reinstatement of food-seeking behaviour. Food-deprived mice were first trained to acquire stable responding on fixed ratio (FR) schedules of reinforcement and then treated twice daily with saline, 3 or 30 mg/kg MDMA during four consecutive days.
RESULTS: The high dose of MDMA impaired instrumental responding on the first and third day of treatment, whilst no residual effects were apparent on FR5 responding at any of the doses studied 24 h after treatment withdrawal. Breaking points were decreased in mice treated with both doses of MDMA. This decrease in motivation for palatable food was not due to unspecific locomotor or coordination deficits. A resistance to extinction was observed only with the highest dose of MDMA, whilst all mice showed similar reinstatement of palatable food-seeking behaviour irrespective of previous treatment. Autoradiography of [3H]-mazindol binding revealed a decrease in striatal dopamine transporter binding only in mice treated with the highest dose of MDMA.
CONCLUSIONS: This study demonstrates that repeated treatment with MDMA decreases the incentive motivation for a palatable food reward and that long-lasting MDMA-induced dopaminergic neurotoxicity increases the resistance to extinction of responding in the absence of reward.
Ainhoa Plaza-Zabala; Xavier Viñals; Rafael Maldonado; Patricia Robledo
Related Documents :
16811353 - Auto-shaping in bobwhite quail.
9037783 - Key-peck probability and topography in a concurrent variable-interval variable-interval...
25062683 - Corticostriatal control of goal-directed action is impaired in schizophrenia.
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychopharmacology     Volume:  208     ISSN:  1432-2072     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2011-04-11     Completed Date:  2011-06-21     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  563-73     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Conditioning, Operant / drug effects*
Corpus Striatum / drug effects,  metabolism,  radionuclide imaging
Dopamine Plasma Membrane Transport Proteins / metabolism
Dose-Response Relationship, Drug
Extinction, Psychological / drug effects*
Mice, Inbred Strains
Motivation / drug effects*
Motor Activity / drug effects
N-Methyl-3,4-methylenedioxyamphetamine / administration & dosage,  pharmacology*
Psychomotor Performance / drug effects
Radioligand Assay / methods
Reinforcement Schedule
Rotarod Performance Test / methods
Grant Support
(#5 R01 DA016768/DA/NIDA NIH HHS
Reg. No./Substance:
0/Dopamine Plasma Membrane Transport Proteins; 10028-17-8/Tritium; KE1SEN21RM/N-Methyl-3,4-methylenedioxyamphetamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The rapid hydrolysis of chlordiazepoxide to demoxepam may affect the outcome of chronic osmotic mini...
Next Document:  Simulating simultanagnosia: spatially constricted vision mimics local capture and the global process...