| Effects of the renin-angiotensin-aldosterone system on the cardiovascular system during 20-days bed rest. | |
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MedLine Citation:
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PMID: 11541179 Owner: NASA Status: MEDLINE |
Abstract/OtherAbstract:
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Long term change of renin-angiotensin-aldosterone system (RAAS) induced by bed rest and its effects on cardiovascular system are still controversial. The purpose of this study was to obtain a general conclusion on these questions by analyzing our two 20-days horizontal bed rest experiments in past two years with 18 subjects. Plasma renin activity and aldosterone were consistently increased during the bed rest, but angiotensin II was increased only during the early days. Decrease in urinary sodium excretion and increase in urinary potassium excretion were observed during day 3-8 and day 7-12, respectively. Mean arterial pressure increased during day 3-8. Pulse pressure was returned to pre-bed rest level by day 10 after an initial decrease. All these results indicated an activated RAAS and its active effects on cardiovascular and overall fluid regulating systems during our horizontal bed rest studies. Direct effect of change in gravitational force on renal pressure-sensitive cells or effects related to physical inactivity may explain our results. |
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Authors:
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Y Haruna; F Bonde-Petersen; K Takenaka; Y Suzuki; K Kawakubo; A Gunji |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology Volume: 4 ISSN: 1077-9248 ISO Abbreviation: J Gravit Physiol Publication Date: 1997 Jan |
Date Detail:
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Created Date: 1998-11-29 Completed Date: 1998-11-29 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 9437868 Medline TA: J Gravit Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: S62-8 Citation Subset: S |
Affiliation:
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Department of Health Administration, University of Tokyo. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aldosterone / blood, metabolism Angiotensin II / blood, metabolism Bed Rest* Blood Pressure Cardiovascular Physiological Phenomena* Circadian Rhythm / physiology Female Heart Rate Humans Hypotension, Orthostatic / etiology, physiopathology Male Potassium / urine Renin / blood, metabolism Renin-Angiotensin System / physiology* Sodium / urine Urine Weightlessness Simulation |
| Chemical | |
Reg. No./Substance:
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11128-99-7/Angiotensin II; 52-39-1/Aldosterone; 7440-09-7/Potassium; 7440-23-5/Sodium; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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