Document Detail

Effects of renal sympathetic denervation on heart rate and atrioventricular conduction in patients with resistant hypertension.
MedLine Citation:
PMID:  22917547     Owner:  NLM     Status:  Publisher    
BACKGROUND: Renal sympathetic denervation (RDN) reduces sympathetic activity and blood pressure (BP) in patients with resistant hypertension. The present study aimed to investigate the effects of RDN on HR and other electrocardiographic parameters. METHODS: 136 patients aged 62.2±0.8years (58% male, BP 177±2/93±1mmHg) with resistant hypertension underwent RDN. BP and a 12-lead electrocardiogram (ECG) were recorded before, 3months (n=127), and 6months (n=88) after RDN. RESULTS: After 3months (3M) and 6months (6M), systolic BP was reduced by 25.5±2.4mmHg (p<0.0001) and 28.1±3mmHg (p<0.0001). HR at baseline was 66.1±1beats per minute (bpm) and was reduced by 2.6±0.8bpm after 3months (p=0.001) and 2.1±1.1bpm after 6months (p=0.046). Patients with HR at baseline between 60-71bpm and ≥71bpm had a reduction of 2.9±7.6bpm (p=0.008) and 9.0±8.6bpm (p<0.0001), respectively, whereas in patients with baseline HR<60bpm HR slightly increased after 3months (2.7±8.4bpm; p=0.035). Neither baseline HR nor change of HR correlated with the reduction of systolic BP. The PR interval was prolonged by 11.3±2.5ms (p<0.0001) and 10.3±2.5ms (p<0.0001) at 3 and 6months after RDN, respectively. CONCLUSIONS: Renal sympathetic denervation reduced heart rate and the PR interval as indicators of cardiac autonomic activity.
Christian Ukena; Felix Mahfoud; Aline Spies; Ingrid Kindermann; Dominik Linz; Bodo Cremers; Ulrich Laufs; Hans-Ruprecht Neuberger; Michael Böhm
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-20
Journal Detail:
Title:  International journal of cardiology     Volume:  -     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
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