Document Detail

Effects on renal function and digoxin-like immunoreactivity produced by methimazole in low-renal mass hypertension.
MedLine Citation:
PMID:  1424215     Owner:  NLM     Status:  MEDLINE    
This study evaluates the effects of methimazole, an antithyroid drug, on blood pressure, digoxin-like immunoreactive factor (DLIF) production and other variables related to salt and water metabolism in low-renal mass (LRM) hypertension. Drinking administration of methimazole (0.025%) from replacement of water by the 1% NaCl solution maintained the blood pressure of low-renal mass rats at normal levels during four weeks after hypertension induction. Serum and urinary excretion of DLIF were significantly increased in LRM rats with respect to controls; in all tests, the highest values of DLIF were found in LRM-methimazole treated (LRM-M) rats. Urinary excretion of DLIF showed positive correlations with diuresis and natriuresis in all three groups (control, LRM and LRM-M rats). However, the correlation between DLIF and sodium disappeared when both factors were expressed as a function of their concentrations. These results indicate that methimazole prevents LRM hypertension and suggest that DLIF might not represent the putative natriuretic hormone. Other findings were that methimazole-treatment reduced renal compensatory hypertrophy subsequent to subtotal nephrectomy, and did not modify the characteristic polyuria-polydypsia in this type of hypertension.
J L Andrade; J M Haro; J M Sabio; C Garcia del Rio; F Vargas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental hypertension. Part A, Theory and practice     Volume:  14     ISSN:  0730-0077     ISO Abbreviation:  Clin Exp Hypertens A     Publication Date:  1992  
Date Detail:
Created Date:  1992-12-08     Completed Date:  1992-12-08     Revised Date:  2008-02-12    
Medline Journal Info:
Nlm Unique ID:  8207790     Medline TA:  Clin Exp Hypertens A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1003-16     Citation Subset:  IM    
Departamento de Bioquímica, Facultad de Medicina, Granada, Spain.
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MeSH Terms
Blood Proteins / metabolism*,  urine
Digoxin / metabolism*,  urine
Hypertension / blood,  metabolism*,  pathology
Isotonic Solutions / pharmacology
Kidney / physiopathology*
Methimazole / pharmacology*
Potassium / urine
Rats, Wistar
Saline Solution, Hypertonic / pharmacology
Sodium Chloride / pharmacology
Water Deprivation
Reg. No./Substance:
0/Blood Proteins; 0/Cardenolides; 0/Isotonic Solutions; 0/Saline Solution, Hypertonic; 0/Saponins; 0/digoxin-like factors; 20830-75-5/Digoxin; 60-56-0/Methimazole; 7440-09-7/Potassium; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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