Document Detail


Effects of renal failure on blood levels of cimetidine.
MedLine Citation:
PMID:  620915     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serial blood samples for determination of drug levels were obtained after intravenous administration of 300 mg of cimetidine. Sixteen patients with varying degrees of renal failure were studied. There was a prolongation of drug half-life in patients with renal insufficiency compared with that in normal controls (P less than 0.001). A significant inverse relationship between the half-life and the creatinine clearance was noted (r= 0.69; P less than 0.01). The effect of hemodialysis was studied in 12 patients. Cimetidine was found to be dialyzable. This was demonstrated both by a shortening of the half-life of the drug during dialysis and by measurement of dialysance. This suggests that the dose schedule should be modified for patients with renal insufficiency and for those on hemodialysis. A single intraveno us dose of cimetidine was well tolerated by the patients. One patient developed an urticarial skin rash, believed to be allergic in nature. There was a transient, mild (but significant) rise in blood urea nitrogen and serum creatinine concentration in 5 patients with moderate renal failure.
Authors:
K W Ma; D C Brown; D S Masler; S E Silvis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gastroenterology     Volume:  74     ISSN:  0016-5085     ISO Abbreviation:  Gastroenterology     Publication Date:  1978 Feb 
Date Detail:
Created Date:  1978-03-29     Completed Date:  1978-03-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  473-7     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blood Urea Nitrogen
Cimetidine / blood*
Creatinine / blood
Guanidines / blood*
Half-Life
Humans
Kidney Failure, Chronic / blood*
Male
Middle Aged
Renal Dialysis
Chemical
Reg. No./Substance:
0/Guanidines; 51481-61-9/Cimetidine; 60-27-5/Creatinine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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