| Effects of renal denervation of the contralateral kidney on blood pressure and sodium and eicosanoid excretion in the chronic phase of two-kidney, one-clip renovascular hypertension in rats. | |
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MedLine Citation:
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PMID: 15764265 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To define the role of the renal nerves of the contralateral kidney in the maintenance of two-kidney, one-clip (2K-1C) renovascular hypertension in rats. MATERIAL AND METHODS: The contralateral kidney of 2K-1C rats was denervated 6 months after induction of hypertension and 4 weeks after nephrectomy of the clipped kidney. Blood pressure, sodium and potassium balance and eicosanoid excretion were measured. RESULTS: Denervation of the contralateral kidney induced normalization of blood pressure in post-Goldblatt hypertensive rats. This effect was not mediated by a negative sodium balance. Excretion of prostaglandin E2 and thromboxane B2 increased after denervation of the contralateral kidney in both post-Goldblatt hypertensive and post-Goldblatt normotensive rats, while urine extraction remained unaffected. CONCLUSION: Afferences from the contralateral kidney appear to participate in the maintenance of 2K-1C renovascular hypertension due to the activation of central mechanisms regulating blood pressure. |
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Authors:
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Christos Kalaitzis; Stavros Touloupidis; Evangelos Bantis; Emmanuel Patris; Argyrios Triantafyllidis |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Scandinavian journal of urology and nephrology Volume: 39 ISSN: 0036-5599 ISO Abbreviation: Scand. J. Urol. Nephrol. Publication Date: 2005 |
Date Detail:
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Created Date: 2005-03-14 Completed Date: 2005-08-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0114501 Medline TA: Scand J Urol Nephrol Country: Sweden |
Other Details:
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Languages: eng Pagination: 15-20 Citation Subset: IM |
Affiliation:
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Department of Urology, University of Thrace, 68100 Alexandroupolis, Greece. chkalaitzis@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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6-Ketoprostaglandin F1 alpha
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urine Animals Blood Pressure / physiology Denervation Dinoprostone / urine Eicosanoids / urine* Hypertension, Renovascular / metabolism*, physiopathology Kidney / innervation* Male Rats Rats, Sprague-Dawley Sodium / metabolism Thromboxane B2 / urine Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Eicosanoids; 363-24-6/Dinoprostone; 54397-85-2/Thromboxane B2; 58962-34-8/6-Ketoprostaglandin F1 alpha; 7440-23-5/Sodium |
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