| Effects of rehabilitative exercise on peripheral muscle TNFalpha, IL-6, IGF-I and MyoD expression in patients with COPD. | |
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MedLine Citation:
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PMID: 17573449 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Skeletal muscle wasting commonly occurs in patients with chronic obstructive pulmonary disease (COPD) and has been associated with the presence of systemic inflammation. This study investigated whether rehabilitative exercise training decreases the levels of systemic or local muscle inflammation or reverses the abnormalities associated with muscle deconditioning. METHODS: Fifteen patients with COPD (mean (SE) forced expiratory volume in 1 s 36 (4)% predicted) undertook high-intensity exercise training 3 days/week for 10 weeks. Before and after the training programme the concentration of tumour necrosis factor alpha (TNFalpha), interleukin-6 (IL-6) and C-reactive protein (CRP) in plasma was determined by ELISA, and vastus lateralis mRNA expression of TNFalpha, IL-6, total insulin-like growth factor-I (IGF-I) and its isoform mechanogrowth factor (MGF) and myogenic differentiation factor D (MyoD) were assessed by real-time PCR. Protein levels of TNFalpha, IGF-I and MyoD were measured by Western blotting. RESULTS: Rehabilitation improved peak exercise work rate by 10 (2%) (p = 0.004) and mean fibre cross-sectional area from 4061 (254) microm(2) to 4581 (241) microm(2) (p = 0.001). Plasma inflammatory mediators and vastus lateralis expression of TNFalpha and IL-6 were not significantly modified by training. In contrast, there was a significant increase in mRNA expression of IGF-I (by 67 (22)%; p = 0.044), MGF (by 67 (15)%; p = 0.002) and MyoD (by 116 (30)%; p = 0.001). The increase observed at the mRNA level was also seen at the protein level for IGF-I (by 72 (36)%; p = 0.046) and MyoD (by 67 (21)%; p = 0.012). CONCLUSIONS: Pulmonary rehabilitation can induce peripheral muscle adaptations and modifications in factors regulating skeletal muscle hypertrophy and regeneration without decreasing the levels of systemic or local muscle inflammation. |
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Authors:
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Ioannis Vogiatzis; Grigoris Stratakos; Davina C M Simoes; Gerasimos Terzis; Olga Georgiadou; Charis Roussos; Spyros Zakynthinos |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2007-06-15 |
Journal Detail:
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Title: Thorax Volume: 62 ISSN: 0040-6376 ISO Abbreviation: Thorax Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-10-29 Completed Date: 2008-01-23 Revised Date: 2010-11-02 |
Medline Journal Info:
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Nlm Unique ID: 0417353 Medline TA: Thorax Country: England |
Other Details:
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Languages: eng Pagination: 950-6 Citation Subset: IM |
Affiliation:
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National and Kapodistrian University of Athens - Thorax Foundation, 3 Ploutarhou Str 106 75, Athens, Greece. gianvog@phed.uoa.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Exercise Therapy* Female Forced Expiratory Volume / physiology Humans Insulin-Like Growth Factor I / metabolism* Interleukin-6 / metabolism Male Muscle, Skeletal / metabolism* MyoD Protein / metabolism* Pulmonary Disease, Chronic Obstructive / metabolism*, rehabilitation RNA, Messenger / metabolism Tumor Necrosis Factor-alpha / metabolism* Vital Capacity |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-6; 0/MyoD Protein; 0/RNA, Messenger; 0/Tumor Necrosis Factor-alpha; 67763-96-6/Insulin-Like Growth Factor I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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