Document Detail

Effects of regression of cardiac hypertrophy on myocardial contractility and ventricular myosin isoenzymes.
MedLine Citation:
PMID:  1488059     Owner:  NLM     Status:  MEDLINE    
The effects of regression of cardiac hypertrophy on myocardial contractility and ventricular myosin isoenzymes were investigated in rats with renovascular hypertension. Six-week-old male Wistar rats were made hypertensive by constriction of one renal artery with a silver clip. Regression of cardiac hypertrophy was induced following the lowering of blood pressure by nephrectomy on the affected side 5-6 weeks after constriction of the renal artery and was maintained for 5-6 weeks. In contrast, myocardial hypertrophy was induced by 10-11 weeks of the hypertensive state. Isometric developed tension of isolated left ventricular papillary muscles was measured, while they were being perfused with Tyrode solution. Left ventricular myosin isoenzymes were separated by pyrophosphate gel electrophoresis. The ventricular to body weight ratio of the nephrectomized group was significantly lower than that of the hypertensive group, although it was greater than that of age-matched normal control rats. There were no significant differences in the isometric developed tension among three groups, the nephrectomized, hypertensive, and normal control rats. However, dT/dtmax tended to decrease in the hypertensive rats and recovered to normal in the nephrectomized rats. The left ventricular myosin isoenzyme pattern was shifted toward VM-3 in hypertensive rats and was shifted back toward VM-1 again in nephrectomized rats.
T Iwai; N Takeda; M Tuchiya; T Arino; A Tanamura; M Nagano
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular and cellular biochemistry     Volume:  118     ISSN:  0300-8177     ISO Abbreviation:  Mol. Cell. Biochem.     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-02-19     Completed Date:  1993-02-19     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0364456     Medline TA:  Mol Cell Biochem     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  99-103     Citation Subset:  IM    
Department of Internal Medicine, Aoto Hospital, Jikei University School of Medicine, Tokyo, Japan.
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MeSH Terms
Blood Pressure
Body Weight
Cardiomegaly / enzymology,  etiology,  physiopathology*
Heart Ventricles
Hypertension, Renovascular / physiopathology*,  surgery
Isoenzymes / metabolism*
Myocardial Contraction*
Myocardium / enzymology*
Myosins / metabolism*
Organ Size
Rats, Wistar
Reference Values
Reg. No./Substance:
0/Isoenzymes; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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