| Effects of reflex stimuli on blood flow to the adrenal medulla. | |
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MedLine Citation:
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PMID: 2764139 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The goal of this study was to examine changes in blood flow to the adrenal medulla during reflex stimuli that release catecholamines. Adrenal blood flow was measured with microspheres during exercise in conscious dogs and during bicuculline-induced seizures in anesthetized dogs. In awake dogs, blood flow to the adrenal cortex and adrenal medulla was 310 +/- 48 and 1,613 +/- 258 (SE) ml.min-1.100 g-1, respectively. Blood flow to the cortex and medulla was not affected by moderate exercise. Anesthesia (pentobarbital sodium) reduced blood flow to the adrenal cortex and medulla to 158 +/- 12 and 243 +/- 24 ml.min-1.100 g-1, respectively. In anesthetized dogs, seizures markedly increased blood flow to the adrenal medulla (282 +/- 68 to 1,257 +/- 128 ml.min-1.100 g-1), and this response was blocked by sectioning the greater splanchnic nerve. Vasodilator responses of the adrenal medulla to adenosine were not impaired by adrenal denervation. Blood flow to the adrenal cortex was not affected by seizures but increased in response to intravenous adenosine. These findings suggest that 1) anesthesia decreases adrenal blood flow, particularly to the adrenal medulla, and 2) reflex stimuli that release catecholamines can produce selective increases in blood flow to the adrenal medulla. |
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Authors:
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F M Faraci; W M Chilian; J K Williams; D D Heistad |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 257 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1989 Aug |
Date Detail:
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Created Date: 1989-09-14 Completed Date: 1989-09-14 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: H590-6 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine
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pharmacology Adrenal Cortex / blood supply, innervation Adrenal Medulla / blood supply*, innervation Anesthesia, General Animals Blood Pressure / drug effects Denervation Dogs Heart Rate Microspheres Pentobarbital / pharmacology Physical Exertion Radioisotopes Reference Values Reflex* Regional Blood Flow / drug effects Vascular Resistance |
| Grant Support | |
ID/Acronym/Agency:
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HL-14388/HL/NHLBI NIH HHS; HL-38901/HL/NHLBI NIH HHS; NS-24621/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Radioisotopes; 58-61-7/Adenosine; 76-74-4/Pentobarbital |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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