Document Detail


Effects of reduced tidal volume ventilation on pulmonary function in mice before and after acute lung injury.
MedLine Citation:
PMID:  17690203     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated the influence of load impedance on ventilator performance and the resulting effects of reduced tidal volume (Vt) on lung physiology during a 30-min ventilation of normal mice and 10 min of additional ventilation following lavage-induced injury at two positive end-expiratory pressure (PEEP) levels. Respiratory mechanics were regularly monitored, and the lavage fluid was tested for the soluble E-cadherin, an epithelial cell adhesion molecule, and surfactant protein (SP) B. The results showed that, due to the load dependence of the delivered Vt from the small-animal ventilator: 1) uncontrolled ventilation in normal mice resulted in a lower delivered Vt (6 ml/kg at 3-cmH(2)O PEEP and 7 ml/kg at 6-cmH(2)O PEEP) than the prescribed Vt (8 ml/kg); 2) at 3-cmH(2)O PEEP, uncontrolled ventilation in normal mice led to an increase in lung parenchymal functional heterogeneity, a reduction of SP-B, and an increase in E-cadherin; 3) at 6-cmH(2)O PEEP, ventilation mode had less influence on these parameters; and 4) in a lavage model of acute respiratory distress syndrome, delivered Vt decreased to 4 ml/kg from the prescribed 8 ml/kg, which resulted in severely compromised lung function characterized by increases in lung elastance, airway resistance, and alveolar tissue heterogeneity. Furthermore, the low Vt ventilation also resulted in poor survival rate independent of PEEP. These results highlight the importance of delivering appropriate Vt to both the normal and injured lungs. By leaving the Vt uncompensated, it can significantly alter physiological and biological responses in mice.
Authors:
Apiradee Thammanomai; Arnab Majumdar; Erzsébet Bartolák-Suki; Béla Suki
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2007-08-09
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  103     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-29     Completed Date:  2008-01-08     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1551-9     Citation Subset:  IM    
Affiliation:
Dept. of Biomedical Engineering, Boston Univ., Boston, MA 02215, USA.
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MeSH Terms
Descriptor/Qualifier:
Airway Resistance
Animals
Biomechanics
Bronchoalveolar Lavage Fluid / chemistry
Cadherins / metabolism
Disease Models, Animal
Lung / metabolism,  pathology,  physiopathology*
Lung Compliance
Male
Mice
Mice, Inbred C57BL
Models, Biological
Positive-Pressure Respiration* / instrumentation
Pulmonary Surfactant-Associated Protein B / metabolism
Respiratory Distress Syndrome, Adult / metabolism,  pathology,  physiopathology,  therapy*
Respiratory Mechanics
Tidal Volume*
Time Factors
Grant Support
ID/Acronym/Agency:
HL-076372/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Cadherins; 0/Pulmonary Surfactant-Associated Protein B

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