Document Detail

Effects of reduced coronary flow reserve on left ventricular function in type 2 diabetes.
MedLine Citation:
PMID:  18722029     Owner:  NLM     Status:  MEDLINE    
AIMS: Diabetic patients without clinical evidence of cardiovascular disease may develop left ventricular (LV) dysfunction. The present study was designed to test the hypothesis that coronary microvascular dysfunction affects LV function in type 2 diabetic patients. METHODS: The study subjects were 20 type 2 diabetic patients and 15 controls, who had been angiographically determined to have normal coronary arteries. LV ejection fraction (LVEF) and the percentage change in LVEF during dobutamine infusion (DeltaLVEF) were measured as an index of LV function. In order to evaluate coronary flow reserve, coronary flow velocity was recorded using a Doppler guide wire. RESULTS: There were no significant differences in LVEF. DeltaLVEF was significantly lower in the diabetic patients than in the control subjects (p<0.01). Although there was no significant difference in the baseline coronary volumetric flow between the two groups, values during maximal hyperemia were significantly less in the diabetic patients than in the controls (p<0.05). Consequently, coronary flow reserve was significantly lower (p=0.0001). A significant positive correlation between coronary flow reserve and DeltaLVEF was exhibited (r=0.68, p=0.0009). CONCLUSIONS: Coronary flow reserve, an indicator of coronary microvascular function, is significantly reduced in type 2 diabetes, and this is reflected in impairment of myocardial contractile reserve.
Osamu Yonaha; Tatsuaki Matsubara; Keiko Naruse; Hideki Ishii; Toyoaki Murohara; Jiro Nakamura; Tetsuya Amano; Nigishi Hotta
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Publication Detail:
Type:  Journal Article     Date:  2008-08-21
Journal Detail:
Title:  Diabetes research and clinical practice     Volume:  82     ISSN:  1872-8227     ISO Abbreviation:  Diabetes Res. Clin. Pract.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-06     Completed Date:  2009-02-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8508335     Medline TA:  Diabetes Res Clin Pract     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  98-103     Citation Subset:  IM    
Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
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MeSH Terms
Coronary Circulation / physiology*
Coronary Vessels / pathology,  physiopathology
Diabetes Mellitus, Type 2 / complications,  physiopathology*
Middle Aged
Ventricular Dysfunction, Left / etiology,  physiopathology*
Ventricular Function, Left

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