Document Detail

Effects of red blood cell transfusions during the first week of life on acid-base, glucose, and electrolytes in preterm neonates.
MedLine Citation:
PMID:  18647369     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: More than 90 percent of extremely low-birth-weight infants receive one or more transfusions of red blood cells (RBCs). The objective was to assess if RBC transfusions may induce significant changes of plasma acid-base, electrolyte, and glucose status in extremely preterm infants. STUDY DESIGN AND METHODS: Records of infants with gestational age of less than 31 weeks who were transfused with RBCs during the first week of life were reviewed (n = 61). Blood samples were collected from infants before and after transfusions to evaluate hemoglobin (Hb) level, hematocrit, acid-base, electrolyte, and glucose status. Then infants were stratified into four groups that received a RBC volume of less than 15, 15 to 20, more than 20 to 25, or more than 25 mL per kg. RESULTS: Infants received 20.7 (+/-1.5) mL per kg RBCs. After transfusions, a significant increase of pO(2) (p < 0.0001) and decrease of Ca(2+) (p = 0.047) and glycemia (p < 0.0001) were observed. Infants who were transfused with more than 25 mL per kg were significantly less immature, heavier, and more anemic than infants in other groups. A positive relationship was found between changes of patients' potassium plasma level and K(+) intake through RBC transfusion (r = 0.442, p = 0.008). Three (4.9%) infants developed hyperkalemia, one (1.6%) had an exacerbation of his hypocalcemia, and another (1.6%) of his hypoglycemia. CONCLUSIONS: RBC transfusions were effective in correcting anemia in our patients and induced a slight increase of pH and pO(2) and decrease of Ca(2+) and glycemia, which were not clinically relevant. A linear direct correlation was observed between potassium intake by RBC transfusions and changes of kalemia in our infants, but there was not an increase of K(+) plasma level after transfusions.
Carlo Dani; Silvia Perugi; Alessandra Benuzzi; Iuri Corsini; Giovanna Bertini; Simone Pratesi; Firmino F Rubaltelli
Related Documents :
21382469 - The developing oligodendrocyte: key cellular target in brain injury in the premature in...
9039519 - The effect of blood transfusion on oxygenation in premature ventilated neonates.
21391229 - Total brain white matter is a major determinant of iq in adolescents born preterm.
21501429 - Neonatal resuscitation and immediate newborn assessment and stimulation for the prevent...
7028339 - Red blood cell volume in preterm neonates.
8129449 - Prognosis in cystic fibrosis treated with continuous flucloxacillin from the neonatal p...
18834739 - Health care-associated outbreak of salmonella tennessee in a neonatal intensive care unit.
2028869 - John caffey award. determination of functional residual capacity from digital radiograp...
23543519 - Prophylactic oral/topical non-absorbed antifungal agents to prevent invasive fungal inf...
Publication Detail:
Type:  Journal Article     Date:  2008-07-17
Journal Detail:
Title:  Transfusion     Volume:  48     ISSN:  1537-2995     ISO Abbreviation:  Transfusion     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-12-04     Completed Date:  2009-01-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417360     Medline TA:  Transfusion     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2302-7     Citation Subset:  IM    
Department of Surgical and Medical Critical Care, Section of Neonatology, Careggi University Hospital of Florence, Florence, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acid-Base Equilibrium*
Anemia / blood,  therapy*
Anoxia / blood,  therapy
Blood Glucose / analysis*
Electrolytes / blood*
Erythrocyte Transfusion* / adverse effects
Gestational Age
Hyperkalemia / etiology
Hypocalcemia / etiology
Hypoglycemia / etiology
Infant, Newborn
Infant, Newborn, Diseases / blood,  therapy
Infant, Premature / blood*
Infant, Very Low Birth Weight / blood*
Retrospective Studies
Reg. No./Substance:
0/Blood Glucose; 0/Electrolytes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Role of lactadherin in the clearance of phosphatidylserine-expressing red blood cells.
Next Document:  Meta-analysis: an introduction into a research process.