Document Detail

Effects of recombinant murine interferon-gamma on pregnant mice and their fetuses.
MedLine Citation:
PMID:  2113876     Owner:  NLM     Status:  MEDLINE    
Recombinant murine interferon-gamma (Rec-MuIFN-gamma) was administered intramuscularly to C3H/HeNCrj mice on Days 6-15 of gestation at dosage levels of 8 X 10(5), 4 X 10(6), and 2 X 10(7) u/kg/day. Dams were killed for examination of fetuses on Day 18 of gestation. Pregnant females that received 2 X 10(7) u/kg/day of Rec-MuIFN-gamma showed uterine bleeding on Days 10-15 of gestation and could not maintain their pregnancy. These dams died on Days 13-17 or were killed in extremis on Days 10-15 for examination, and therefore no fetal data were available for this group. In the 2 X 10(7) u/kg/day group, the mean absolute weights of the lung and spleen increased and the mean absolute weight of the liver, red blood cells (RBC), hematocrit, and hemoglobin decreased significantly. Surviving dams in the 8 X 10(5) and 4 X 10(6) u/kg/day groups showed significant increases in the mean absolute weights of the lung, liver, kidneys, and spleen and a decrease in platelet count. Significant increases in the weights of the heart and ovaries and decreases in RBC, hematocrit, and hemoglobin were observed in the 4 X 10(6) u/kg/day group. Histopathological examination revealed increased extramedullary hematopoiesis in the spleen of the 4 X 10(6) and 2 X 10(7) u/kg/day groups. Fetuses showed no external, visceral, or skeletal malformations and variations caused by the administration of Rec-MuIFN-gamma in any of the treated groups.(ABSTRACT TRUNCATED AT 250 WORDS)
I Kato; S Kimura; T Furuhashi; H Nakayoshi; S Takayama; N Uenishi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fundamental and applied toxicology : official journal of the Society of Toxicology     Volume:  14     ISSN:  0272-0590     ISO Abbreviation:  Fundam Appl Toxicol     Publication Date:  1990 May 
Date Detail:
Created Date:  1990-08-06     Completed Date:  1990-08-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8200838     Medline TA:  Fundam Appl Toxicol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  658-65     Citation Subset:  IM    
NRI Life Science, Kanagawa, Japan.
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MeSH Terms
Body Weight / drug effects
Embryonic and Fetal Development / drug effects*
Interferon-gamma, Recombinant / pharmacology*
Mice, Inbred Strains
Pregnancy, Animal / drug effects*
Reg. No./Substance:
0/Interferon-gamma, Recombinant

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