Document Detail


Effects of recombinant human superoxide dismutase during reoxygenation with 21% or 100% oxygen after cerebral asphyxia in newborn piglets.
MedLine Citation:
PMID:  14629089     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Superoxide radicals (O2-) are generated during reoxygenation following asphyxia, possibly more when higher concentrations of O2 are used during resuscitation. Superoxide dismutase (SOD) is an antioxidant enzyme, which scavenges O2-. We tested the hypothesis that a single intravenous dose of recombinant human Cu,Zn SOD (rhSOD) could influence microcirculation and biochemical markers of asphyxia in piglets reoxygenated with 21% or 100% O2 after combined cerebral hypoxemia-ischemia-hypercapnia. METHODS: Anesthetized newborn piglets were randomized to asphyxia (n = 40) or control (n = 3). Asphyxia was induced by ventilation with 8% O2, adding CO2, and temporary occlusion of both common carotid arteries. After 20 min, 16 piglets received rhSOD 5 mg/kg intravenously and reoxygenation with 21% O2 (rhSOD, 21%; n = 8) or 100% O2 (rhSOD, 100%; n = 8), and 24 piglets received saline and reoxygenation with 21% O2 (21%, n = 13) or 100% O2 (100%, n = 11). The cortical microcirculation was assessed by laser Doppler flowmetry, and glutamate in the striatum and hypoxanthine in the cortex were measured by in vivo microdialysis. RESULTS AND CONCLUSION: rhSOD peaked in plasma after 5 min. No rhSOD was detected in brain tissue. There were no significant differences between rhSOD and non-rhSOD groups in any measured variable.
Authors:
A B Solås; P Kalous; J M Davis; O D Saugstad
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  14     ISSN:  1476-7058     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-11-21     Completed Date:  2004-01-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  96-101     Citation Subset:  IM    
Affiliation:
Department of Pediatric Research, The National Hospital, Oslo, Norway.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Blood Flow Velocity
Disease Models, Animal
Free Radical Scavengers / administration & dosage*,  blood,  metabolism
Humans
Hypoxia-Ischemia, Brain / metabolism,  physiopathology,  therapy*
Injections, Intravenous
Laser-Doppler Flowmetry
Microcirculation
Oxygen Inhalation Therapy*
Random Allocation
Recombinant Proteins / administration & dosage,  blood,  metabolism
Reperfusion
Superoxide Dismutase / administration & dosage*,  blood,  metabolism
Swine
Telencephalon / blood supply*
Chemical
Reg. No./Substance:
0/Free Radical Scavengers; 0/Recombinant Proteins; EC 1.15.1.1/Superoxide Dismutase
Comments/Corrections
Comment In:
J Matern Fetal Neonatal Med. 2003 Aug;14(2):73-4   [PMID:  14629085 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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