Document Detail


Effects of rebreathing conditions and body size on normal human lung tissue volume.
MedLine Citation:
PMID:  2707405     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To evaluate the consequences of breathing pattern variations inherent to lung disease on the rebreathing measurement of lung tissue volume (Vt), we carried out a study of ten normal human subjects in whom we assessed the effects of changes in rebreathing volume (Vreb), additional deadspace volume (AVD), respiratory rate (RR), and body height. Vt and alveolar volume (VA) were determined from the end-tidal concentrations of acetylene and helium. We performed Vt measurements using different combinations of Vreb (20, 30 and 50% of predicted vital capacity), of AVD (0, 100, and 200 ml) and of RR (10, 25, and 40 br.min-1). Only slow RR (10 br.min-1) resulted in a higher Vt (p less than 0.001). An increase in Vreb induced an increase in VA but not in Vt. VA and Vt were positively correlated with the height of the subjects. We conclude that, in normal subjects, Vt increases: 1) with the height of subjects; and 2) when the respiratory rate is low. Interpretation of Vt results must take into account these two variables.
Authors:
J M Polianski; P D Vivet; T C Chinet; S I Labrune; D G Henzel; G J Huchon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The European respiratory journal     Volume:  2     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-06-02     Completed Date:  1989-06-02     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  78-83     Citation Subset:  IM    
Affiliation:
Université René Descartes, Unité INSERM 214, Hôpital Laënnec, France.
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MeSH Terms
Descriptor/Qualifier:
Acetylene / analysis
Adult
Body Height*
Helium / analysis
Humans
Lung / physiology*
Mass Spectrometry
Middle Aged
Respiration*
Respiratory Dead Space
Vital Capacity
Grant Support
ID/Acronym/Agency:
HL 19155/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
74-86-2/Acetylene; 7440-59-7/Helium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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