Document Detail

Effects of reamed or unreamed intramedullary nailing under non-damaged conditions on pulmonary function in sheep.
MedLine Citation:
PMID:  16361908     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Pulmonary damage after reamed or unreamed femoral nailing has been controversial in clinical and experimental studies. We investigated changes in pulmonary function and coagulatory response in normal lungs of sheep after reamed or unreamed intramedullary nailing of an unfractured femur. METHODS: We used three groups of sheep (each group, n = 6): reamed femoral nailing (RFN); unreamed femoral nailing (UFN); and sham control group. Femoral osteotomies and lung contusions were not made. Hemodynamic monitoring data and blood gas data (BGD) were recorded, and blood samples for biochemistry (antithrombin III, lipid peroxidase and fibrinogen) were collected 0 to 6 hours after nailing. Bronchoalveolar lavage fluid (BALF) and myeloperoxidase (MPO) activity in pulmonary tissue were analyzed 6 hours after nailing. RESULTS: There were no significant differences in time course of hemodynamic monitoring data, BGD, or biochemical data among the three groups. In BALF analysis, the lipid-laden cell count in the RFN group was higher than those of the other groups, and MPO activity was highest in the RFN group. CONCLUSION: RFN did not affect pulmonary function at the physiologic level or affect the coagulatory system at the acute stage, but RFN under non-damaged conditions could lead to leukocyte activation in lung tissue without worse alteration of alveolar permeability in the acute post-operative course.
Shinichi Aoki; Kazuhiko Yokoyama; Moritoshi Itoman
Related Documents :
20832588 - Establishment of a porcine model for lobar lung auto-transplantation.
16534568 - Peep has beneficial effects on inflammation in the injured and no deleterious effects o...
2433798 - Improved lung preservation using euro-collins solution for flush-perfusion.
7775318 - Effect of rbc shape and deformability on pulmonary o2 diffusing capacity and resistance...
12944028 - Interactions of l-arginine, isosorbide mononitrate, and angiotensin ii inhibitors on ar...
20959788 - Limiting ventilator-induced lung injury through individual electronic medical record su...
Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  The Journal of trauma     Volume:  59     ISSN:  0022-5282     ISO Abbreviation:  -     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-12-19     Completed Date:  2006-02-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376373     Medline TA:  J Trauma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  647-58     Citation Subset:  AIM; IM    
Department of Orthopaedic Surgery, School of Medicine, Kitasato University, Sagamihara, Kanagawa, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Analysis of Variance
Bone Nails*
Bronchoalveolar Lavage Fluid / chemistry
Femoral Fractures
Fracture Fixation, Intramedullary / methods*
Lung / metabolism
Peroxidase / metabolism
Random Allocation
Respiratory Mechanics*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Long-term mortality following trauma: 10 year follow-up in a population-based sample of injured adul...
Next Document:  Emergent stabilization of pelvic ring injuries by controlled circumferential compression: a clinical...