Document Detail


Effects of reamed or unreamed intramedullary nailing under non-damaged conditions on pulmonary function in sheep.
MedLine Citation:
PMID:  16361908     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Pulmonary damage after reamed or unreamed femoral nailing has been controversial in clinical and experimental studies. We investigated changes in pulmonary function and coagulatory response in normal lungs of sheep after reamed or unreamed intramedullary nailing of an unfractured femur. METHODS: We used three groups of sheep (each group, n = 6): reamed femoral nailing (RFN); unreamed femoral nailing (UFN); and sham control group. Femoral osteotomies and lung contusions were not made. Hemodynamic monitoring data and blood gas data (BGD) were recorded, and blood samples for biochemistry (antithrombin III, lipid peroxidase and fibrinogen) were collected 0 to 6 hours after nailing. Bronchoalveolar lavage fluid (BALF) and myeloperoxidase (MPO) activity in pulmonary tissue were analyzed 6 hours after nailing. RESULTS: There were no significant differences in time course of hemodynamic monitoring data, BGD, or biochemical data among the three groups. In BALF analysis, the lipid-laden cell count in the RFN group was higher than those of the other groups, and MPO activity was highest in the RFN group. CONCLUSION: RFN did not affect pulmonary function at the physiologic level or affect the coagulatory system at the acute stage, but RFN under non-damaged conditions could lead to leukocyte activation in lung tissue without worse alteration of alveolar permeability in the acute post-operative course.
Authors:
Shinichi Aoki; Kazuhiko Yokoyama; Moritoshi Itoman
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Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  The Journal of trauma     Volume:  59     ISSN:  0022-5282     ISO Abbreviation:  -     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-12-19     Completed Date:  2006-02-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0376373     Medline TA:  J Trauma     Country:  United States    
Other Details:
Languages:  eng     Pagination:  647-58     Citation Subset:  AIM; IM    
Affiliation:
Department of Orthopaedic Surgery, School of Medicine, Kitasato University, Sagamihara, Kanagawa, Japan.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Bone Nails*
Bronchoalveolar Lavage Fluid / chemistry
Femoral Fractures
Fracture Fixation, Intramedullary / methods*
Hemodynamics
Lung / metabolism
Male
Peroxidase / metabolism
Random Allocation
Respiratory Mechanics*
Sheep
Chemical
Reg. No./Substance:
EC 1.11.1.7/Peroxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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