| Effects of rapid smoking. Physiologic evaluation of a smoking-cessation therapy. | |
| | |
MedLine Citation:
|
PMID: 646248 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We studied 24 healthy young male smokers to ascertain the medical safety of a highly effective smoking-abatement technique called rapid smoking. In comparison with results obtained after a 12-h cigarette fast or after normal smoking, statistically significant increases occurred after rapid smoking in heart and respiratory rates, systolic blood pressure, carboxyhemoglobin, and pH (p less than 0.05), while arterial PCO2, HCO3-, and serum [K+] fell (p less than 0.05). Rapid smoking produced alveolar hyperventilation in all subjects. In eight, arterial PO2 increased appropriately, but in 16, fell paradoxically (p less than 0.01); seven had arterial PO2 below 80 torr. Because this fall could represent ventilation/perfusion mismatch due to early bronchoconstrictive disease, in subjects with normal flow/volume loops and spirometry rapid smoking may be a simple, provocative screening test for early airway disease. Despite the changes produced there were no arrhythmias. Rapid smoking is safe for healthy subjects but should not now be used for higher-risk patients. |
| | |
Authors:
|
D P Sachs; R G Hall; S M Hall |
Related Documents
:
|
6681178 - Alcohol, personality and predisposition to essential hypertension. 7760888 - Suppression of alcohol-induced hypertension by dexamethasone. 1036418 - Lowering of blood acetaldehyde levels-a possible approach to prevention of alcoholic ca... 7841238 - Differences in the association between alcohol consumption and blood pressure by age, g... 3795458 - Hemodynamic response to exercise in patients 2 to 6 years after rastelli operation. 2306468 - Loss of cardiac contractility and severe morphologic changes by acutely lowering the ph... |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: Annals of internal medicine Volume: 88 ISSN: 0003-4819 ISO Abbreviation: Ann. Intern. Med. Publication Date: 1978 May |
Date Detail:
|
Created Date: 1978-06-28 Completed Date: 1978-06-28 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0372351 Medline TA: Ann Intern Med Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 639-41 Citation Subset: AIM; IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aversive Therapy* Hemodynamics Humans Male Oxygen / blood* Smoking / complications* Substance Withdrawal Syndrome |
| Chemical | |
Reg. No./Substance:
|
7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Carcinoembryonic antigen assay of ascites and detection of malignancy.
Next Document: Ovarian (corpus luteum) hemorrhage during anticoagulation therapy.