Document Detail

Effects of rapid saline infusion on lung mechanics and airway responsiveness in humans.
MedLine Citation:
PMID:  12730149     Owner:  NLM     Status:  MEDLINE    
Lung mechanics and airway responsiveness to methacholine (MCh) were studied in seven volunteers before and after a 20-min intravenous infusion of saline. Data were compared with those of a time point-matched control study. The following parameters were measured: 1-s forced expiratory volume, forced vital capacity, flows at 40% of control forced vital capacity on maximal (Vm(40)) and partial (Vp(40)) forced expiratory maneuvers, lung volumes, lung elastic recoil, lung resistance (Rl), dynamic elastance (Edyn), and within-breath resistance of respiratory system (Rrs). Rl and Edyn were measured during tidal breathing before and for 2 min after a deep inhalation and also at different lung volumes above and below functional residual capacity. Rrs was measured at functional residual capacity and at total lung capacity. Before MCh, saline infusion caused significant decrements of forced expiratory volume in 1 s, Vm(40), and Vp(40), but insignificantly affected lung volumes, elastic recoil, Rl, Edyn, and Rrs at any lung volume. Furthermore, saline infusion was associated with an increased response to MCh, which was not associated with significant changes in the ratio of Vm(40) to Vp(40). In conclusion, mild airflow obstruction and enhanced airway responsiveness were observed after saline, but this was not apparently due to altered elastic properties of the lung or inability of the airways to dilate with deep inhalation. It is speculated that it was likely the result of airway wall edema encroaching on the bronchial lumen.
Riccardo Pellegrino; Raffaele Dellaca; Peter T Macklem; Andrea Aliverti; Stefania Bertini; Pamela Lotti; PierGiuseppe Agostoni; Alessandro Locatelli; Vito Brusasco
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial     Date:  2003-05-02
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  95     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-07-09     Completed Date:  2004-03-19     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  728-34     Citation Subset:  IM    
Fisiopatoloia Respiratoria, Azienda Ospedaliera S Croce e Carle, Cuneo.
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MeSH Terms
Administration, Inhalation
Airway Obstruction / chemically induced,  physiopathology
Forced Expiratory Volume
Infusions, Intravenous
Lung / drug effects*,  physiology*
Methacholine Chloride / administration & dosage*
Respiratory Function Tests
Respiratory Physiological Phenomena*
Respiratory System / drug effects*
Severity of Illness Index
Sodium Chloride / administration & dosage*
Time Factors
Vital Capacity
Reg. No./Substance:
62-51-1/Methacholine Chloride; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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