Document Detail


Effects of rapamycin and TOR on aging and memory: Implications for Alzheimer's disease.
MedLine Citation:
PMID:  21447003     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Rapamycin is a macrolide immunosuppressant drug, originally used as an antifungal agent, which is widely used in transplantation medicine to prevent organ rejection. Target of Rapamycin (TOR) is an evolutionarily conserved serine/threonine kinase with pleiotropic cellular functions, regulating processes such as growth and metabolism, cell survival, transcription and autophagy. TOR intervenes in two distinct enzymatic complexes with different functions, a rapamycin-sensitive complex TORC1 and a rapamycin-insensitive complex TORC2. Rapamycin has an inhibitory effect on TORC1 activity and it has been suggested to increase life span, an effect correlated with decreased protein biosynthesis and autophagy activation. In the central nervous system, rapamycin shows beneficial effects in neuronal survival and plasticity, thus contributing to memory improvement. In this review evidence implying rapamycin and TOR in aging/life span extension and memory improvement will be discussed. Recent findings about the effects of rapamycin on Alzheimer's disease-associated neuropathology will be also discussed.
Authors:
R X Santos; S C Correia; S Cardoso; C Carvalho; M S Santos; P I Moreira
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-3-29
Journal Detail:
Title:  Journal of neurochemistry     Volume:  -     ISSN:  1471-4159     ISO Abbreviation:  -     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-3-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Journal of Neurochemistry © 2011 International Society for Neurochemistry.
Affiliation:
Department of Life Sciences - Faculty of Sciences and Technology Center for Neuroscience and Cell Biology Institute of Physiology - Faculty of Medicine, University of Coimbra, 3000-354 Coimbra, Portugal.
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