| Effects of ramiprilat-coated stents on neointimal hyperplasia, inflammation, and arterial healing in a porcine coronary restenosis model. | |
| | |
MedLine Citation:
|
PMID: 22022329 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND AND OBJECTIVES: The renin-angiotensin-aldosterone system has been implicated in the pathogenesis of neointimal hyperplasia, and a role for angiotensin II in the migration and proliferation of vascular smooth muscle cells in restenotic lesions has been proposed. The aim of this study was to determine the anti-proliferative and anti-inflammatory effects of ramiprilat-coated stents in a porcine coronary overstretch restenosis model. SUBJECTS AND METHODS: Pigs were randomized into two groups in which the coronary arteries {16 pigs (16 coronaries in each group)} had a 3.0×17 mm ramiprilat-coated MAC stent or a 3.0×17 mm control MAC stent (AMG, Munich, Germany) implanted with oversizing (stent-to-artery ratio, 1.3 : 1) in porcine coronary arteries, and histopathologic analysis was assessed 28 days after stenting. RESULTS: There were no significant differences in the injury and inflammation scores between the two groups (1.20±0.43 vs. 1.23±0.57, p=0.8; and 1.21±0.39 vs. 1.25±0.49, p=0.6, respectively). Within the neointima, most inflammatory cells were lymphohistiocytes. Significant positive correlations existed between inflammatory cell counts and the neointima areas (r=0.567, p<0.001), and between inflammatory cell counts and the percent area stenosis (r=0.478, p<0.001). There was no significant difference in the inflammatory cell counts normalized to the injury (110±89 vs. 123±83, p=0.4) and fibrin scores (0.15±0.06 vs. 0.17±0.07, p=0.8) between the 2 groups. There were trends toward a smaller neointima area (1.06±0.51 mm(2) vs. 1.28±0.35 mm(2), p=0.083) and a smaller percent area stenosis (18.9±8.7% vs. 21.8±7.2%, p=0.088) in the ramiprilat-coated stent group. CONCLUSION: Although the ramiprilat-coated stent did not show significant inhibitory effects on neointimal hyperplasia, the ramiprilat-coated stent showed good effects on the inflammatory reaction and arterial healing similar to the control stent in a porcine coronary restenosis model. |
| | |
Authors:
|
Young Joon Hong; Myung Ho Jeong; Sun-Jung Song; Doo Sun Sim; Jung Ha Kim; Kyung Seob Lim; Daisuke Hachinohe; Khurshid Ahmed; Seung Hwan Hwang; Min Goo Lee; Jum Suk Ko; Keun-Ho Park; Hyun Ju Yoon; Nam Sik Yoon; Kye Hun Kim; Hyung Wook Park; Ju Han Kim; Youngkeun Ahn; Jeong Gwan Cho; Dong Lyun Cho; Jong Chun Park; Jung Chaee Kang |
Related Documents
:
|
16174049 - Impact of aging on penile hemodynamics in men responding normally to prostaglandin inje... 9126909 - Bilateral superior ophthalmic vein enlargement associated with diffuse cerebral swellin... 9517849 - Development of the murine pulmonary vein and its relationship to the embryonic venous s... 2345899 - The paratemporal segment of the maxillary sinus: a new sign for assessment of size. 21982039 - Assessment of autonomic control of the heart during transient myocardial ischemia. 20810059 - Spontaneous resolution of direct carotid cavernous fistula. 19966369 - X-ray angiography and magnetic resonance imaging to distinguish interarterial from sept... 9308109 - Radiographic appearances of esophageal stents. 22688129 - Multi-detector computed tomography is equivalent to trans-oesophageal echocardiography ... |
Publication Detail:
|
Type: Journal Article Date: 2011-09-29 |
Journal Detail:
|
Title: Korean circulation journal Volume: 41 ISSN: 1738-5555 ISO Abbreviation: Korean Circ J Publication Date: 2011 Sep |
Date Detail:
|
Created Date: 2011-10-24 Completed Date: 2011-11-10 Revised Date: 2013-05-29 |
Medline Journal Info:
|
Nlm Unique ID: 101247141 Medline TA: Korean Circ J Country: Korea (South) |
Other Details:
|
Languages: eng Pagination: 535-41 Citation Subset: - |
Affiliation:
|
The Heart Center of Chonnam National University Hospital, Chonnam National University Research Institute of Medical Sciences, Gwangju, Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Treadmill exercise stress echocardiography in patients with no history of coronary artery disease: a...
Next Document: A case of left atrial metastasis from hepatocellular carcinoma: life-saving palliative resection usi...