| Effects of raloxifene on the renin-angiotensin-aldosterone system and blood pressure in hypertensive and normotensive osteoporotic postmenopausal women. | |
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MedLine Citation:
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PMID: 20102385 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: An increase in blood pressure after menopause has been documented. The renin-angiotensin-aldosterone system (RAAS) plays a central role in the regulation of blood pressure and in the pathophysiology of hypertension. This study investigated the effects of raloxifene, a selective estrogen receptor modulator, on components of the RAAS and blood pressure in hypertensive and normotensive osteoporotic postmenopausal women. METHODS: A total of 41 hypertensive or normotensive postmenopausal women with osteoporosis or osteopenia were divided into four groups. Eleven hypertensive and eight normotensive women received raloxifene hydrochloride (60 mg/day) p.o. for 6 months, and 12 hypertensive and 10 normotensive women did not receive raloxifene hydrochloride for 6 months. In all of the hypertensive women, blood pressure had been controlled prior to the start of the study using a variety of antihypertensive drugs other than angiotensin-converting enzyme (ACE) inhibitors, angiotensin (Ang)II type 1 receptor antagonists or diuretics. Plasma renin activity (PRA), serum ACE activity, plasma AngI, AngII and aldosterone concentrations, and blood pressure were measured before and 6 months after the start of the study. RESULTS: No significant changes in PRA, ACE activity, or the AngI, AngII or aldosterone levels were observed in any of the groups. In all the groups, blood pressure remained unchanged. CONCLUSION: Raloxifene may have no significant effect on the RAAS or blood pressure in hypertensive and normotensive osteoporotic postmenopausal women. |
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Authors:
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Hiroyuki Sumino; Shuichi Ichikawa; Shu Kasama; Takashi Takahashi; Hisao Kumakura; Yoshiaki Takayama; Tsugiyasu Kanda; Masami Murakami; Masahiko Kurabayashi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Geriatrics & gerontology international Volume: 10 ISSN: 1447-0594 ISO Abbreviation: Geriatr Gerontol Int Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-27 Completed Date: 2010-05-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101135738 Medline TA: Geriatr Gerontol Int Country: Japan |
Other Details:
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Languages: eng Pagination: 70-7 Citation Subset: IM |
Affiliation:
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Department of Nursing, Faculty of Nursing, Takasaki University of Health and Welfare, Takasaki, Gunma, Japan. hsumino@takasaki-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antihypertensive Agents / therapeutic use Blood Pressure / drug effects* Case-Control Studies Female Humans Hypertension / drug therapy, physiopathology Middle Aged Osteoporosis, Postmenopausal / drug therapy, physiopathology* Raloxifene / pharmacology* Renin-Angiotensin System / drug effects* Selective Estrogen Receptor Modulators / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents; 0/Selective Estrogen Receptor Modulators; 84449-90-1/Raloxifene |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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