Document Detail


Effects of raloxifene on the renin-angiotensin-aldosterone system and blood pressure in hypertensive and normotensive osteoporotic postmenopausal women.
MedLine Citation:
PMID:  20102385     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: An increase in blood pressure after menopause has been documented. The renin-angiotensin-aldosterone system (RAAS) plays a central role in the regulation of blood pressure and in the pathophysiology of hypertension. This study investigated the effects of raloxifene, a selective estrogen receptor modulator, on components of the RAAS and blood pressure in hypertensive and normotensive osteoporotic postmenopausal women. METHODS: A total of 41 hypertensive or normotensive postmenopausal women with osteoporosis or osteopenia were divided into four groups. Eleven hypertensive and eight normotensive women received raloxifene hydrochloride (60 mg/day) p.o. for 6 months, and 12 hypertensive and 10 normotensive women did not receive raloxifene hydrochloride for 6 months. In all of the hypertensive women, blood pressure had been controlled prior to the start of the study using a variety of antihypertensive drugs other than angiotensin-converting enzyme (ACE) inhibitors, angiotensin (Ang)II type 1 receptor antagonists or diuretics. Plasma renin activity (PRA), serum ACE activity, plasma AngI, AngII and aldosterone concentrations, and blood pressure were measured before and 6 months after the start of the study. RESULTS: No significant changes in PRA, ACE activity, or the AngI, AngII or aldosterone levels were observed in any of the groups. In all the groups, blood pressure remained unchanged. CONCLUSION: Raloxifene may have no significant effect on the RAAS or blood pressure in hypertensive and normotensive osteoporotic postmenopausal women.
Authors:
Hiroyuki Sumino; Shuichi Ichikawa; Shu Kasama; Takashi Takahashi; Hisao Kumakura; Yoshiaki Takayama; Tsugiyasu Kanda; Masami Murakami; Masahiko Kurabayashi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Geriatrics & gerontology international     Volume:  10     ISSN:  1447-0594     ISO Abbreviation:  Geriatr Gerontol Int     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-27     Completed Date:  2010-05-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101135738     Medline TA:  Geriatr Gerontol Int     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  70-7     Citation Subset:  IM    
Affiliation:
Department of Nursing, Faculty of Nursing, Takasaki University of Health and Welfare, Takasaki, Gunma, Japan. hsumino@takasaki-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Aged
Antihypertensive Agents / therapeutic use
Blood Pressure / drug effects*
Case-Control Studies
Female
Humans
Hypertension / drug therapy,  physiopathology
Middle Aged
Osteoporosis, Postmenopausal / drug therapy,  physiopathology*
Raloxifene / pharmacology*
Renin-Angiotensin System / drug effects*
Selective Estrogen Receptor Modulators / pharmacology*
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 0/Selective Estrogen Receptor Modulators; 84449-90-1/Raloxifene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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