| Effects of raloxifene on body fat distribution and lipid profile in healthy post-menopausal women. | |
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MedLine Citation:
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PMID: 16218045 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of our prospective, randomised, controlled and open-label clinical study was to evaluate in healthy post-menopausal women the effects of raloxifene (RLX) on body fat distribution and lipids, and the correlations between these parameters. The fat distribution, by dual energy X-ray absorptiometry, and lipids were evaluated at baseline and after 1 yr in 50 post-menopausal women: 25 were treated with RLX 60 mg/die, while 25 served as control group (CG). After 1 yr, we observed in RLX-users a slight reduction of fat mass in trunk and central region and an increase in legs and, in relation to CG, significantly lower values of adiposity in trunk and abdominal region (p < 0.05). At the same time, HDL-cholesterol (HDL-C) and apolipoprotein A1 (ApoA1) were significantly increased in relation to baseline values and CG (p < 0.05) and apolipoprotein B (ApoB), total cholesterol/HDL-C, LDL cholesterol/ HDL-C, and ApoB/ApoA1 ratios significantly decreased compared to baseline values and CG (p < 0.05). No correlation was underlined among lipids and regional fat distribution. These results highlight the positive effect of RLX on lipids and suggest, for the first time, that RLX promotes the shift from android to gynoid fat distribution, and prevents the uptrend of abdominal adiposity and body weight compared with untreated women. |
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Authors:
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C M Francucci; P Daniele; D Pantaleo; N Iori; A Camilletti; F Massi; M Boscaro |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Journal of endocrinological investigation Volume: 28 ISSN: 0391-4097 ISO Abbreviation: J. Endocrinol. Invest. Publication Date: 2005 Jul-Aug |
Date Detail:
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Created Date: 2005-10-12 Completed Date: 2006-01-06 Revised Date: 2006-01-09 |
Medline Journal Info:
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Nlm Unique ID: 7806594 Medline TA: J Endocrinol Invest Country: Italy |
Other Details:
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Languages: eng Pagination: 623-31 Citation Subset: IM |
Affiliation:
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Division of Endocrinology, Department of Internal Medicine, University of Ancona, Italy. cm.francucci@ao-umbertoprimo.marche.it |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Apolipoproteins / blood Blood Glucose Body Composition Body Fat Distribution* Cardiovascular Diseases / physiopathology Female Humans Lipids / blood* Lipoproteins / blood Middle Aged Postmenopause / drug effects*, physiology Prospective Studies Raloxifene / pharmacology* Selective Estrogen Receptor Modulators / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins; 0/Blood Glucose; 0/Lipids; 0/Lipoproteins; 0/Selective Estrogen Receptor Modulators; 84449-90-1/Raloxifene |
| Comments/Corrections | |
Erratum In:
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J Endocrinol Invest. 2005 Oct;28(9):868 Note: Pantaleo, D [corrected to Daniele, P] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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