Document Detail


Effects of raloxifene on body fat distribution and lipid profile in healthy post-menopausal women.
MedLine Citation:
PMID:  16218045     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of our prospective, randomised, controlled and open-label clinical study was to evaluate in healthy post-menopausal women the effects of raloxifene (RLX) on body fat distribution and lipids, and the correlations between these parameters. The fat distribution, by dual energy X-ray absorptiometry, and lipids were evaluated at baseline and after 1 yr in 50 post-menopausal women: 25 were treated with RLX 60 mg/die, while 25 served as control group (CG). After 1 yr, we observed in RLX-users a slight reduction of fat mass in trunk and central region and an increase in legs and, in relation to CG, significantly lower values of adiposity in trunk and abdominal region (p < 0.05). At the same time, HDL-cholesterol (HDL-C) and apolipoprotein A1 (ApoA1) were significantly increased in relation to baseline values and CG (p < 0.05) and apolipoprotein B (ApoB), total cholesterol/HDL-C, LDL cholesterol/ HDL-C, and ApoB/ApoA1 ratios significantly decreased compared to baseline values and CG (p < 0.05). No correlation was underlined among lipids and regional fat distribution. These results highlight the positive effect of RLX on lipids and suggest, for the first time, that RLX promotes the shift from android to gynoid fat distribution, and prevents the uptrend of abdominal adiposity and body weight compared with untreated women.
Authors:
C M Francucci; P Daniele; D Pantaleo; N Iori; A Camilletti; F Massi; M Boscaro
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of endocrinological investigation     Volume:  28     ISSN:  0391-4097     ISO Abbreviation:  J. Endocrinol. Invest.     Publication Date:    2005 Jul-Aug
Date Detail:
Created Date:  2005-10-12     Completed Date:  2006-01-06     Revised Date:  2006-01-09    
Medline Journal Info:
Nlm Unique ID:  7806594     Medline TA:  J Endocrinol Invest     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  623-31     Citation Subset:  IM    
Affiliation:
Division of Endocrinology, Department of Internal Medicine, University of Ancona, Italy. cm.francucci@ao-umbertoprimo.marche.it
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MeSH Terms
Descriptor/Qualifier:
Aged
Apolipoproteins / blood
Blood Glucose
Body Composition
Body Fat Distribution*
Cardiovascular Diseases / physiopathology
Female
Humans
Lipids / blood*
Lipoproteins / blood
Middle Aged
Postmenopause / drug effects*,  physiology
Prospective Studies
Raloxifene / pharmacology*
Selective Estrogen Receptor Modulators / pharmacology*
Chemical
Reg. No./Substance:
0/Apolipoproteins; 0/Blood Glucose; 0/Lipids; 0/Lipoproteins; 0/Selective Estrogen Receptor Modulators; 84449-90-1/Raloxifene
Comments/Corrections
Erratum In:
J Endocrinol Invest. 2005 Oct;28(9):868
Note: Pantaleo, D [corrected to Daniele, P]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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