| Effects of radiographic contrast agents on spinal cord physiology. | |
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MedLine Citation:
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PMID: 7263159 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Segmental reflexes in the spinal cords of cats anesthetized with chloralose were used to evaluate the neurophysiologic effects of radiographic contrast agents. The exposed lumbar spinal cord was bathed with concentrations of ionic and nonionic agents including saline, sodium meglumine diatrizoate, meglumine iothalamate, meglumine iocarmate, and metrizamide. The following responses were evaluated: flexor and extensor monosynaptic reflex; polysynaptic flexion reflexes; spontaneous ventral root activity. Hypertonic solutions generally produced a transient decrease in all reflex activity for up to 1 hour. Isotonic solutions produced no significant changes in the monosynaptic responses, but an increase in amplitude of polysynaptic responses, and increased spontaneous activity. The usual facilitory effects of flexion reflex on the flexor monosynaptic reflex were unchanged, but the expected inhibitory effect of flexion reflex on the extensor monosynaptic reflex was changed to excitatory. The relative ability to produced these effects was sodium meglumine diatrizoate greater than meglumine iothalamate greater than meglumine iocarmate greater than metrizamide. |
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Authors:
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R N Bryan; G W Dauth; S Gilman; S K Hilal |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Investigative radiology Volume: 16 ISSN: 0020-9996 ISO Abbreviation: Invest Radiol Publication Date: 1981 May-Jun |
Date Detail:
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Created Date: 1981-10-14 Completed Date: 1981-10-14 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0045377 Medline TA: Invest Radiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 234-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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drug effects Animals Cats Contrast Media / toxicity* Diatrizoate Meglumine / toxicity Iothalamate Meglumine / toxicity Iothalamic Acid / analogs & derivatives, toxicity Meglumine / toxicity Metrizamide / toxicity Reflex / drug effects Spinal Cord / drug effects* Spinal Nerve Roots / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 13087-53-1/Iothalamate Meglumine; 131-49-7/Diatrizoate Meglumine; 2276-90-6/Iothalamic Acid; 31112-62-6/Metrizamide; 54605-45-7/iocarmate meglumine; 6284-40-8/Meglumine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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