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Effects of radiofrequency catheter ablation on left ventricular structure and function in patients with atrial fibrillation: a meta-analysis.
MedLine Citation:
PMID:  24966021     Owner:  NLM     Status:  Publisher    
INTRODUCTION: Radiofrequency catheter ablation (RFCA) is an effective therapy for atrial fibrillation (AF). This study was designed to investigate the effects of RFCA on left ventricular (LV) structure and function in AF patients.
METHODS AND RESULTS: A systematic literature search in MEDLINE, EMBASE, and Cochrane Central Register of Controlled Trials was performed to identify trials involving changes of LV structure and function in AF patients undergoing RFCA. Effect size was expressed as weighted mean difference (WMD) with 95 % confidence interval (CI). LV end-diastolic diameter (LVEDD), LV end-systolic diameter (LVESD), LV end-diastolic volume (LVEDV), LV end-systolic volume (LVESV), and LV ejection fraction (LVEF) were estimated. A total of 21 trials including 1,135 participants were qualified for this meta-analysis. Compared to the baseline values, there were significant decreases in LVEDV (WMD, -6.39 ml; 95 %CI, -12.46 to -0.33) and LVESV (WMD, -6.39 ml; 95 %CI, -11.35 to -1.42) and a significant improvement in LVEF (WMD, 6.23 %; 95 %CI, 3.70 to 8.75), but no significant changes were observed in LVEDD (WMD, -0.64 mm; 95 %CI, -2.40 to 1.13) and LVESD (WMD, -0.38 mm; 95 %CI, -1.32 to 0.56) after RFCA. Subgroup analysis demonstrated that patients with low LVEF (WMD, 11.90 %; 95 %CI, 9.16 to 14.64) gained more benefits than those with normal LVEF (WMD, 1.56 %; 95 %CI, 0.38 to 2.74). Besides, patients with chronic AF (WMD, 10.96 %; 95 %CI, 4.92 to 17.01) improved more than those with paroxysmal AF (WMD, 1.93 %; 95 %CI, -0.27 to 4.12).
CONCLUSIONS: RFCA in AF patients could reverse LV structural remodeling and improve LV systolic function, especially in patients with low LVEF and chronic AF.
Pengju Zhu; Yong Zhang; Peiqing Jiang; Zhongsu Wang; Jiangrong Wang; Xiangcui Yin; Yinglong Hou
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-26
Journal Detail:
Title:  Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing     Volume:  -     ISSN:  1572-8595     ISO Abbreviation:  J Interv Card Electrophysiol     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-26     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9708966     Medline TA:  J Interv Card Electrophysiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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