| Effects of rabbit gastrointestinal mucins and dextran on hydrochloride diffusion in vitro. | |
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MedLine Citation:
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PMID: 11007177 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We compared a viscous fingering formation of hydrochloric acid (HCl) in rabbit corpus, antral and duodenal mucins and with dextran under neutral and acidic conditions with respect to relative viscosity, molecular mass, and carbohydrate composition. The effect of desialyzation of duodenal mucin on the viscous fingering formation of HCl was also examined. HCl (0.1 N) was injected into 1% solutions of mucins and dextran and a subsequent viscous fingering formation was assessed based on an influx volume rate of HCl. A low influx volume rate indicates a high ability of the solutions to produce viscous fingers. The influx volume rate of HCl was lowest in duodenal mucin followed bl corpus mucin, antral mucin, and dextran at pH 7. The influx volume rate of HCl was inversely correlated with the relative viscosity of the solution. Maximum molecular masses were large in the order of corpus, antral, and duodenal mucins, and they were larger than dextran T2000. Rabbit gastrointestinal mucins were very polydisperse system. Duodenal mucin contains more sialic acid than gastric mucins; the influx volume rate of HCl increased in desialylated duodenal mucin. It is suggested that the higher ability of gastric mucins to prevent HCl diffusion than dextran were due to the differences in the molecular mass. The ability of duodenal mucin to prevent HCl diffusion was probably attributed to its high sialic acid content, which may reflect a physiological role of duodenal mucin in the duodenum that has to deal with HCl influx from the stomach. |
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Authors:
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T Fujita; S Ohara; T Sugaya; K Saigenji; K Hotta |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology Volume: 126 ISSN: 1096-4959 ISO Abbreviation: Comp. Biochem. Physiol. B, Biochem. Mol. Biol. Publication Date: 2000 Jul |
Date Detail:
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Created Date: 2001-02-06 Completed Date: 2001-02-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9516061 Medline TA: Comp Biochem Physiol B Biochem Mol Biol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 353-9 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Kitasato University School of Medicine, Kanagawa, Japan. twata@med.kitasato-u.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Transport Dextrans / metabolism* Diffusion Gastric Mucosa / physiology* Hydrochloric Acid / metabolism* Intestinal Absorption / physiology Intestinal Mucosa / physiology* Mucins / physiology* Rabbits |
| Chemical | |
Reg. No./Substance:
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0/Mucins; 7647-01-0/Hydrochloric Acid; 9004-54-0/Dextrans |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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