Document Detail


Effects of rHuEPO therapy on exercise capacity in hemodialysis patients with coronary artery disease.
MedLine Citation:
PMID:  8450597     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated the effects of recombinant human erythropoietin (rHuEPO) therapy on exercise capacity by symptom-limited maximal treadmill exercise testing in 9 patients with coronary artery disease who were receiving maintenance hemodialysis. The initial hemoglobin concentration of 7.9 +/- 0.7 g/dl, (mean +/- S.D.) rose to 10.4 +/- 1.1 g/dl, (p < 0.01) after three months of rHuEPO therapy. The partial correction of renal anemia resulted in a significant increase in exercise duration (from 278 +/- 84 sec to 384 +/- 74 sec, p < 0.01) and maximum pressure-rate product (from 228.3 +/- 50.3 mmHg.bpm/10(2) to 262.8 +/- 40.4 mmHg.bpm/10(2), p < 0.01). The maximum exercise-induced ST segment depression significantly decreased after treatment (from 1.3 +/- 0.5 mm to 0.5 +/- 0.5 mm, p < 0.05). These results suggest that the improvement in maximum coronary oxygen supply exceeded the increased maximum myocardial oxygen requirements after the partial correction of renal anemia by rHuEPO therapy in hemodialysis patients with coronary artery disease.
Authors:
H Hase; Y Imamura; R Nakamura; Y Inishi; K Machii; T Yamaguchi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  57     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-04-14     Completed Date:  1993-04-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  131-7     Citation Subset:  IM    
Affiliation:
Third Department of Internal Medicine, Toho University Ohashi Hospital, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anemia / etiology,  prevention & control
Coronary Disease / complications*
Erythropoietin / therapeutic use*
Exercise Test*
Female
Humans
Male
Middle Aged
Physical Endurance / drug effects
Recombinant Proteins / therapeutic use
Renal Dialysis / methods*
Chemical
Reg. No./Substance:
0/Recombinant Proteins; 11096-26-7/Erythropoietin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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