Document Detail

Effects of quercetin treatment on vascular function in deoxycorticosterone acetate-salt hypertensive rats. Comparative study with verapamil.
MedLine Citation:
PMID:  15095149     Owner:  NLM     Status:  MEDLINE    
This study analysed and compared the effects of chronic oral treatment with quercetin or verapamil on systolic blood pressure and vascular function in deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Quercetin and verapamil inhibited the development of DOCA-salt-induced hypertension in a similar manner. DOCA-salt-hypertensive rats showed potassium depletion and oxidative stress, prevented only by concomitant quercetin administration. Quercetin and verapamil treatments reduced the endothelium-independent hyper-reactivity to KCl observed in the aorta of DOCA-salt-hypertensive rats, but only quercetin increased the contractile responses to angiotensin II, improved endothelial dysfunction and restored basal aortic Cu/Zn SOD expression, altered in DOCA-salt-treated rats. In conclusion, quercetin and verapamil show similar antihypertensive effects in mineralocorticoid hypertension, but quercetin was superior to verapamil in improving endothelial-dependent aortic dilatation, suggesting a better vascular protection in this volume expansion hypertension model.
Milagros Galisteo; María Francisca García-Saura; Rosario Jiménez; Inmaculada Concepción Villar; Rosemary Wangensteen; Antonio Zarzuelo; Félix Vargas; Juan Duarte
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Planta medica     Volume:  70     ISSN:  0032-0943     ISO Abbreviation:  Planta Med.     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-19     Completed Date:  2004-06-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0066751     Medline TA:  Planta Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  334-41     Citation Subset:  IM    
Department of Pharmacology, School of Pharmacy, University of Granada, Granada, Spain.
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MeSH Terms
Antihypertensive Agents / administration & dosage,  pharmacology*,  therapeutic use
Aorta / drug effects
Blood Pressure / drug effects
Desoxycorticosterone / diagnostic use
Disease Models, Animal
Hypertension / chemically induced,  prevention & control*
Muscle Contraction / drug effects
Plants, Medicinal*
Potassium Chloride / diagnostic use
Quercetin / administration & dosage,  pharmacology*,  therapeutic use
Rats, Wistar
Sodium Chloride / diagnostic use
Verapamil / pharmacology
Reg. No./Substance:
0/Antihypertensive Agents; 117-39-5/Quercetin; 52-53-9/Verapamil; 64-85-7/Desoxycorticosterone; 7447-40-7/Potassium Chloride; 7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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