Document Detail

Effects of pyrrol-carboxylic acid derivatives on the growth of coliphages.
MedLine Citation:
PMID:  330014     Owner:  NLM     Status:  MEDLINE    
Effects of 14 pyrrol-carboxylic acid derivatives and analogues (PY-compounds) on the growth of coliphage MS2 using E. coli E102 (Hfr) as the host were measured by the agar double-layer method. Enlargements of plaque size were observed with 7 PY-compounds but increase in plaque numbers was not induced. These enlargements of plaque size were specific to RNA coliphages MS2, GA and qbeta and not found with DNA coliphages delta AC and T4. Furthermore, the interaction between PY-compound PY-10 and the coliphage MS2 was dependent on the host bacterium (indicator strain). When E102 (Hfr) was used, the enlargement was marked, in the case of substrain W1895 (Hfr) it was less, while in the case of substrain W6 (F+) it was undetectable. The one-step growth of the phage MS2 and the production of intracellular phage MS2 were little affected by the PY-compound PY-10. However, the rate of one-step growth was increased in the early stage after infection. Accordingly, the enlargements of plaque size by the PY-compounds might be correlated with an increase in rate of release of phage particles.
S Yamabe; M Shimizu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemico-biological interactions     Volume:  18     ISSN:  0009-2797     ISO Abbreviation:  Chem. Biol. Interact.     Publication Date:  1977 Aug 
Date Detail:
Created Date:  1977-10-31     Completed Date:  1977-10-31     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  0227276     Medline TA:  Chem Biol Interact     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  143-51     Citation Subset:  IM    
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MeSH Terms
Coliphages / metabolism*
Escherichia coli / metabolism
Plaque Assay
Proline / analogs & derivatives*,  pharmacology
Structure-Activity Relationship
Reg. No./Substance:

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