| Effects of pyridoxalated hemoglobin polyoxyethylene conjugate and stroma-free hemoglobin on renal vascular responsiveness to vasoactive substances in isolated perfused rat kidney. | |
| | |
MedLine Citation:
|
PMID: 8060252 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The effects of pyridoxalated hemoglobin polyoxyethylene conjugate (PHP) and stroma-free hemoglobin (SFH) on vascular responsiveness to various vasoactive substances were examined in isolated perfused rat kidneys. The kidneys isolated from rats were perfused with 6% PHP, 6% SFH, and 6% hydroxyethylstarch (HES) solution at a constant flow rate. Vascular responsiveness to acetylcholine (ACh), nitroglycerin (NG), norepinephrine (NE), and angiotensin-II (ANG-II) was examined by measuring the perfusion pressure (PP). Effects of inhibition of endothelium-derived relaxing factor (EDRF) by NG-monomethyl L-arginine (L-NMMA) on NE-induced and ANG-II-induced renal vascular responses were examined. ACh and NG induced a dose-dependent decrease in perfusion pressure (PP) in all groups. NE and ANG-II induced an increase in PP in all groups, but NE-induced and ANG-II-induced responses in the PHP-perfused and SFH-perfused groups were significantly larger than those in the HES-perfused group. L-NMMA did not alter vascular responsiveness to NE and ANG-II. These results indicate that PHP and SFH do not inhibit EDRF induced by ACh, but hemoglobin moiety per se does augment the vascular responsiveness to NE and ANG-II in the isolated perfused rat kidney. |
| | |
Authors:
|
K Nishi; S Ueda; D Sato; K Nishi |
Publication Detail:
|
Type: In Vitro; Journal Article |
Journal Detail:
|
Title: Artificial organs Volume: 18 ISSN: 0160-564X ISO Abbreviation: Artif Organs Publication Date: 1994 Jun |
Date Detail:
|
Created Date: 1994-09-15 Completed Date: 1994-09-15 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7802778 Medline TA: Artif Organs Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 429-38 Citation Subset: IM |
Affiliation:
|
Department of Pharmacology, Kumamoto University School of Medicine, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Acetylcholine
/
pharmacology Angiotensin II / pharmacology Animals Arginine / analogs & derivatives, pharmacology Blood Substitutes / pharmacology Hemoglobins / pharmacology* Male Nitric Oxide / antagonists & inhibitors, pharmacology Nitroglycerin / pharmacology Norepinephrine / pharmacology Perfusion Polyethylene Glycols / pharmacology* Rats Rats, Wistar Renal Circulation / drug effects* Vasoconstrictor Agents / pharmacology* Vasodilator Agents / pharmacology* omega-N-Methylarginine |
| Chemical | |
Reg. No./Substance:
|
0/Blood Substitutes; 0/Hemoglobins; 0/Polyethylene Glycols; 0/Vasoconstrictor Agents; 0/Vasodilator Agents; 0/hemoglobin, stroma free; 0/pyridoxalated-hemoglobin-polyethylene glycol conjugate; 10102-43-9/Nitric Oxide; 11128-99-7/Angiotensin II; 17035-90-4/omega-N-Methylarginine; 51-41-2/Norepinephrine; 51-84-3/Acetylcholine; 55-63-0/Nitroglycerin; 74-79-3/Arginine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A comparison of molecular clearance rates during continuous hemofiltration and hemodialysis with a n...
Next Document: Noninvasive blood glucose sensors based on near-infrared spectroscopy.