| Effects of purified zearalenone on growth performance, organ size, serum metabolites, and oxidative stress in post-weaning gilts. | |
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MedLine Citation:
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PMID: 21531849 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Zearalenone (ZEA), an estrogenic mycotoxin, is produced mainly by Fusarium fungi. Previous studies indicated that acute ZEA exposure induced oxidative stress and damage in multiple organs. Therefore, the present study was designed to investigate the adverse effects of dietary ZEA (1.1 to 3.2 mg/kg diet) on oxidative stress and organ damage in post-weaning gilts. A total of 20 gilts (L × Y × D) weaned at d 21 with an average BW of 10.36 ± 1.21 kg was used in the study. Gilts were housed in a temperature-controlled room, divided into 4 treatments, and fed a basal diet only (Control) or basal diet supplemented with purified ZEA at a dietary concentration of 1 (ZEA1), 2 (ZEA2), or 3 (ZEA3) mg/kg diet for 18 d ad libitum. The actual ZEA contents (analyzed) were 0, 1.1 ± 0.02, 2.0 ± 0.01, and 3.2 ± 0.02 mg/kg for Control, ZEA1, ZEA2, and ZEA3, respectively. Gilts fed different levels of dietary ZEA grew similarly with no difference in feed intake. Vulva size increased linearly over the 18 d feeding in gilts fed diets containing 1.1 mg/kg ZEA or greater (P < 0.001). Relative weight of genital organs, liver, and kidney increased linearly (P < 0.05) in a ZEA dose-dependent manner. Serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), γ-glutamate transferase (GGT), urea, and creatinine (P < 0.05), and malondialdehyde (MDA) concentrations in both serum and liver (P < 0.001) were also increased linearly in a ZEA dose-dependent manner. However, spleen relative weight (P = 0.002) and activities of total superoxide dismutase (TSOD) and glutathione peroxidase (GSHPx) in both serum and liver (P < 0.05) were decreased linearly as dietary ZEA levels increased. Results showed that besides genital organs, the liver, kidney, and spleen may also be target tissues in young gilts fed diets containing 1.1 to 3.2 mg ZEA/kg for 18 d. Elevated key liver enzymes in the serum suggest progressive liver damage caused by feeding ZEA, and an increase in oxidative stress in gilts is another potential impact of ZEA toxicity in pigs. |
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Authors:
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S Z Jiang; Z B Yang; W R Yang; J Gao; F X Liu; J Broomhead; F Chi |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-29 |
Journal Detail:
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Title: Journal of animal science Volume: - ISSN: 1525-3163 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-5-2 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8003002 Medline TA: J Anim Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Animal Sciences and Technology, Shandong Agricultural University, Tai'an, Shandong, PR China, 271018. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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