Document Detail

Effects of purified herbal extract of Salvia miltiorrhiza on ischemic rat myocardium after acute myocardial infarction.
MedLine Citation:
PMID:  15808885     Owner:  NLM     Status:  MEDLINE    
In the current study, we compared purified Salvia miltiorrhiza extract (PSME) with Angiotensin-converting enzyme inhibitor, Ramipril, in in vitro experiments and also in vivo using animal model of myocardial infarction. PSME was found to have a significantly higher trolox equivalent antioxidant capacity which indicated a great capacity for scavenging free radicals. PSME could also prevent pyrogallo red bleaching and DNA damage. After 2 weeks treatment with PSME or Ramipril, survival rates of rats with experimental myocardial infarction were marginally increased (68.2% and 71.4%) compared with saline (61.5%). The ratios of infarct size to left ventricular size in both PSME-and Ramipril-treated rats were significantly less than that in the saline-treated group. Activity of cardiac antioxidant enzyme superoxide dismutase (SOD) was significant higher while level of Thiobarbituric acid-reactive substances (TBARs) was lower in the PSME treated group. Purified and standardized Chinese herb could provide an alternative regimen for the prevention of ischemic heart disease.
Jian Sun; Shan Hong Huang; Benny K-H Tan; Matt Whiteman; Yi Chun Zhu; Ya Jun Wu; Yeekong Ng; Wei Duan; Yi Zhun Zhu
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Life sciences     Volume:  76     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-04-05     Completed Date:  2005-05-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  2849-60     Citation Subset:  IM    
Department of Pharmacology, National University of Singapore, Singapore.
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MeSH Terms
Analysis of Variance
Antioxidants / therapeutic use*
DNA Damage / drug effects
Drugs, Chinese Herbal / therapeutic use
Gas Chromatography-Mass Spectrometry
Myocardial Infarction / complications*
Myocardial Ischemia / drug therapy*,  etiology
Pyrogallol / analogs & derivatives*
Ramipril / therapeutic use
Rats, Wistar
Salvia miltiorrhiza / chemistry*
Sulfonic Acids
Superoxide Dismutase / metabolism
Thiobarbituric Acid Reactive Substances / metabolism
Ventricular Remodeling / drug effects
Reg. No./Substance:
0/Antioxidants; 0/Benzothiazoles; 0/Drugs, Chinese Herbal; 0/Sulfonic Acids; 0/Thiobarbituric Acid Reactive Substances; 28752-68-3/2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; 32638-88-3/pyrogallol sulfonphthalein; 87-66-1/Pyrogallol; 87333-19-5/Ramipril; EC Dismutase

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