Document Detail


Effects of pure macronutrient ingestion on plasma tryptophan and large neutral amino acids.
MedLine Citation:
PMID:  11842877     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The role of tryptophan and its competitor large neutral amino acids, proposed earlier for serotonin synthesis following carbohydrate or protein ingestion, was reassessed in relation to a recent study investigating serotonin release, including the so far unknown effects of fats. In the present study, meals of either carbohydrates, casein, or lard, were supplied to rats for 30 min and blood samples collected every 15 min to follow the changes in plasma large neutral amino acids. In response to carbohydrates, amino acid levels fell and the ratio tryptophan over sum of other amino acids increased. Following casein ingestion, all amino acids were enhanced, tryptophan somewhat less, leading to a decreased ratio. The lard meal induced a slight decrease in some amino acids while the ratio remained constant. Only in response to casein, and partly to carbohydrates, did a consistent relation appear between the previously observed serotonin changes and the ratio. These data suggest that a relationship between the ratio and the previously observed serotonin changes is not always encountered because the release is not obligatorily coupled to synthesis and is subject to behavioral influences. It remains that serotonin release is affected by the composition of the meal through peripheral metabolic mechanisms.
Authors:
C Rouch; S Nicolaidis; M Orosco
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nutritional neuroscience     Volume:  4     ISSN:  1028-415X     ISO Abbreviation:  Nutr Neurosci     Publication Date:  2001  
Date Detail:
Created Date:  2002-02-14     Completed Date:  2002-03-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  100892202     Medline TA:  Nutr Neurosci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  63-73     Citation Subset:  IM    
Affiliation:
Physiopathologie de la Nutrition, CNRS ESA 7059, Université Paris 7, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Amino Acids, Neutral / blood*
Animal Feed*
Animals
Diet
Fatty Acids, Nonesterified / blood
Kinetics
Male
Rats
Rats, Wistar
Time Factors
Tryptophan / pharmacology*
Chemical
Reg. No./Substance:
0/Amino Acids, Neutral; 0/Fatty Acids, Nonesterified; 73-22-3/Tryptophan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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