Document Detail

Effects of pulmonary thromboendarterectomy on right-sided echocardiographic parameters in patients with chronic thromboembolic pulmonary hypertension.
MedLine Citation:
PMID:  16770978     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine the echocardiographic changes in the heart at 3 months and 1 year after pulmonary thromboendarterectomy (PTE) in patients with chronic thromboembolic pulmonary hypertension (CTEPH).
PATIENTS AND METHODS: Thirty-two adult patients who underwent PTE for CTEPH at the Mayo Clinic in Rochester, Minn, from 1997 to 2003 were included in the study. All underwent transthoracic echocardiography before surgery. Follow-up echocardiography was performed within 3 months of surgery in 28 patients and 1 year postoperatively in 17 patients. The results were compared with baseline data.
RESULTS: Within 3 months after PTE, the right ventricular end-diastolic area decreased from 38.4 +/- 12.8 cm2 to 32.5 +/- 10.4 cm2 (mean difference, 5.8 +/- 10.4 cm2; P = .02). The right ventricular end-systolic area decreased from 30.4 +/- 12.1 cm2 to 24.1 +/- 8.6 cm2 (mean difference, 6.3 +/- 10.1 cm2; P = .008). The right ventricular systolic pressure decreased significantly from 92.6 +/- 22.0 mm Hg to 55.0 +/- 19.8 mm Hg (mean difference, 40.0 +/- 24.8 mm Hg; P < .001). Tricuspid regurgitation (TR) improved from a mean grade of 2.5 +/- 1.2 to 1.2 +/- 1.1 (mean difference, 1.5 +/- 1.0; P < .001). At 12 months, the right ventricular end-diastolic area, right ventricular end-systolic area, right ventricular systolic pressure, and TR also were significantly lower than baseline values.
CONCLUSION: In patients with CTEPH who undergo PTE, echocardiographic measurements of right ventricular size, systolic pressure, and TR show significant improvement immediately after surgery, which is sustained for up to 1 year after surgery.
Grace Casaclang-Verzosa; Robert B McCully; Jae K Oh; Fletcher A Miller; Christopher G A McGregor
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article    
Journal Detail:
Title:  Mayo Clinic proceedings     Volume:  81     ISSN:  0025-6196     ISO Abbreviation:  Mayo Clin. Proc.     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-14     Completed Date:  2006-07-12     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  0405543     Medline TA:  Mayo Clin Proc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  777-82     Citation Subset:  AIM; IM    
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MeSH Terms
Chronic Disease
Echocardiography, Doppler*
Follow-Up Studies
Hypertension, Pulmonary / etiology,  surgery*,  ultrasonography*
Middle Aged
Thromboembolism / complications,  surgery*,  ultrasonography*
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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