| Effects of pulmonary inhalation on hyperpolarized krypton-83 magnetic resonance T1 relaxation. | |
| | |
MedLine Citation:
|
PMID: 21628780 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The (83)Kr magnetic resonance (MR) relaxation time T(1) of krypton gas in contact with model surfaces was previously found to be highly sensitive to surface composition, surface-to-volume ratio, and surface temperature. The work presented here explored aspects of pulmonary (83)Kr T(1) relaxation measurements in excised lungs from healthy rats using hyperpolarized (hp) (83)Kr with approximately 4.4% spin polarization. MR spectroscopy without spatial resolution was applied to the ex vivo lungs that actively inhale hp (83)Kr through a custom designed ventilation system. Various inhalation schemes were devised to study the influence of anatomical dead space upon the measured (83)Kr T(1) relaxation times. The longitudinal (83)Kr relaxation times in the distal airways and the respiratory zones were independent of the lung inhalation volume, with T(1) = 1.3 s and T(1) = 1.0 s, depending only on the applied inhalation scheme. The obtained data were highly reproducible between different specimens. Further, the (83)Kr T(1) relaxation times in excised lungs were unaffected by the presence of up to 40% oxygen in the hp gas mixture. The results support the possible importance of (83)Kr as a biomarker for evaluating lung function. |
| | |
Authors:
|
K F Stupic; N D Elkins; G E Pavlovskaya; J E Repine; T Meersmann |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2011-05-31 |
Journal Detail:
|
Title: Physics in medicine and biology Volume: 56 ISSN: 1361-6560 ISO Abbreviation: Phys Med Biol Publication Date: 2011 Jul |
Date Detail:
|
Created Date: 2011-06-22 Completed Date: 2011-10-21 Revised Date: 2012-01-04 |
Medline Journal Info:
|
Nlm Unique ID: 0401220 Medline TA: Phys Med Biol Country: England |
Other Details:
|
Languages: eng Pagination: 3731-48 Citation Subset: IM |
Affiliation:
|
Sir Peter Mansfield Magnetic Resonance Centre, School of Clinical Sciences, University of Nottingham, Nottingham, NG7 2RD, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Inhalation* Isotopes Krypton / chemistry* Lung / physiology* Magnetic Resonance Spectroscopy / methods* Male Models, Biological Oxygen / chemistry Pulmonary Alveoli / physiology Pulmonary Ventilation Rats Rats, Sprague-Dawley |
| Grant Support | |
ID/Acronym/Agency:
|
G0900785//Medical Research Council; R0-1 25324//PHS HHS |
| Chemical | |
Reg. No./Substance:
|
0/Isotopes; 7439-90-9/Krypton; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A 4 MV flattening filter-free beam: commissioning and application to conformal therapy and volumetri...
Next Document: Helium-vacancy cluster in a single bcc iron crystal lattice.