Document Detail

Effects of pulmonary gas embolism on circulation and respiration in the dog. II. Effects on respiration.
MedLine Citation:
PMID:  558603     Owner:  NLM     Status:  MEDLINE    
In mongrel dogs weighing 15--25 kg and anesthetized with thiopental-gamma-hydroxybutyric acid the effects of venous gas infusion and injection on several respiratory variables were investigated. During spontaneous respiration pulmonary gas embolism caused an increase of the ventilatory minute volume depending on the degree of embolization. The contribution of breathing frequency and tidal volume to the increase of ventilatory minute volume varied from one animal to the other. During constant artificial ventilation pulmonary gas embolism impaired the pulmonary gas exchange depending on the degree of embolization. How far a steady-state phase in gas exchange can be reached during continuous venous gas infusion depended on the adaptation of the circulation. At severe degrees of embolization circulation as well as gas exchange became deficient. Increasing artificial ventilation during pulmonary gas embolism improved the wash-out of carbon dioxide, but hardly affected the uptake of oxygen. The most important origin of the disturbed gas exchange in pulmonary gas embolism seemed to be an increased inequality of the ventilation-perfusion ratio distribution.
F T Verstappen; J A Bernards; F Kreuzer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  368     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  1977 Mar 
Date Detail:
Created Date:  1977-06-22     Completed Date:  1977-06-22     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  97-104     Citation Subset:  IM; S    
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MeSH Terms
Carbon Dioxide / blood
Embolism, Air / physiopathology*
Pulmonary Embolism / physiopathology*
Tidal Volume
Ventilation-Perfusion Ratio
Reg. No./Substance:
124-38-9/Carbon Dioxide

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