Document Detail

Effects of psoralen-UV-A-Turban in alopecia areata.
MedLine Citation:
PMID:  16603835     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Psoralen-UV-A (PUVA)-turban is a modification of PUVA-bath therapy used in alopecia areata. OBJECTIVE: The aim of this study was to assess the efficacy of PUVA-turban in different forms of alopecia areata. Twenty patients completed the study: nine with alopecia areata vulgaris and 11 with alopecia areata totalis or universalis. METHODS: 8-methoxypsoralen in a dilution of 0.0001% (1 mg/L) was administered to the scalp for 20 minutes using a cotton towel as a turban. The application was followed by UV-A radiation. Treatments were performed two or three times weekly. The cumulative doses ranged from 48.2-253.4 J/cm2, and single fractions ranged from 0.3-6.5 J/cm2. RESULTS: Hair regrowth was observed in 15 patients (total regrowth in six patients and partial regrowth in nine patients). Five patients did not respond to the therapy. CONCLUSIONS: PUVA-turban was significantly more effective in alopecia areata vulgaris than in alopecia areata totalis or universalis and proved to be a safe, well tolerated method without the systemic side effects of PUVA.
Grazyna Broniarczyk-Dyla; Anna Wawrzycka-Kaflik; Malgorzata Dubla-Berner; Magdalena Prusinska-Bratos
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Skinmed     Volume:  5     ISSN:  1540-9740     ISO Abbreviation:  Skinmed     Publication Date:    2006 Mar-Apr
Date Detail:
Created Date:  2006-04-10     Completed Date:  2006-08-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  101168327     Medline TA:  Skinmed     Country:  United States    
Other Details:
Languages:  eng     Pagination:  64-8     Citation Subset:  IM    
Department of General, Esthetic Dermatology and Dermatosurgery, Medical University of Lodz, Poland.
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MeSH Terms
Administration, Topical
Alopecia Areata / drug therapy*
Hair / growth & development
Methoxsalen / administration & dosage
Middle Aged
PUVA Therapy / methods*
Photosensitizing Agents / administration & dosage
Reg. No./Substance:
0/Photosensitizing Agents; 298-81-7/Methoxsalen

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