Document Detail

Effects of a protein meal, intraduodenal HCl, and oleic acid on portal and peripheral venous secretin and on pancreatic bicarbonate secretion.
MedLine Citation:
PMID:  25827     Owner:  NLM     Status:  MEDLINE    
We have studied the effect of a protein meal on secretin (IRS) concentration in dogs and humans using a radioimmunoassay of improved sensitivity (8 pg/ml). After a meal, pancreatic bicarbonate secretion (PBS) increased markedly and proximal duodenal pH decreased from 6.2 to 4.3. Portal and peripheral IRS concentrations, however, remained unchanged in eight dogs and five patients with cirrhosis of the liver. Similarly, an alkaline solution of sodium oleate (pH 9.2) stimulated PBS but not IRS. Intraduodenal administration of various amounts of HCl in dogs demonstrated that acid-stimulated PBS was invariably accompanied by rises in peripheral venous IRS concentration. We conclude that the postprandial stimulation of PBS involves mechanisms more complex than acid-stimulated secretin release.
G Boden; R M Wilson; N Essa-Koumar; O E Owen
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Gut     Volume:  19     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1978 Apr 
Date Detail:
Created Date:  1978-07-24     Completed Date:  1978-07-24     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  277-83     Citation Subset:  AIM; IM    
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MeSH Terms
Amino Acids / pharmacology
Bicarbonates / secretion*
Dietary Proteins / administration & dosage*
Hydrochloric Acid / pharmacology*
Hydrogen-Ion Concentration
Middle Aged
Oleic Acids / pharmacology*
Pancreas / secretion*
Portal Vein
Secretin / blood*
Secretory Rate / drug effects
Reg. No./Substance:
0/Amino Acids; 0/Bicarbonates; 0/Dietary Proteins; 0/Oleic Acids; 1393-25-5/Secretin; 7647-01-0/Hydrochloric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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