Document Detail


Effects of prostaglandins on intraocular pressure recovery rate in rabbits.
MedLine Citation:
PMID:  3923565     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The actions of a number of prostaglandins (PGs) were studied in unanesthetized rabbits using an intraocular pressure (IOP) recovery-rate method. In topical doses of 0.1 to 10 micrograms, these compounds accelerated the rate at which IOP returned to control levels after an infusion of hypertonic saline. In general, PGE1 appeared more potent than the other PGs at these doses. Arachidonic acid also increased the IOP recovery rate. The effect of arachidonic acid was completely blocked by the cyclooxygenase inhibitor indomethacin. Recovery rate responses to arachidonic acid were increased further after pretreatment with the lipoxygenase inhibitor phenidone. When administered alone, phenidone itself accelerated IOP recovery; this action was also blocked by indomethacin. The IOP recovery rate method appears to be a useful tool for studying ocular effects of PGs and other products or inhibitors of arachidonic acid metabolism.
Authors:
J P Trzeciakowski; F Y Chiou; K Watanabe; G C Chiou
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Prostaglandins     Volume:  29     ISSN:  0090-6980     ISO Abbreviation:  Prostaglandins     Publication Date:  1985 Mar 
Date Detail:
Created Date:  1985-07-17     Completed Date:  1985-07-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0320271     Medline TA:  Prostaglandins     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  497-510     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Arachidonic Acid
Arachidonic Acids / pharmacology
Dose-Response Relationship, Drug
Indomethacin / pharmacology
Intraocular Pressure / drug effects*
Prostaglandins / pharmacology*
Pyrazoles / pharmacology
Rabbits
Saline Solution, Hypertonic / pharmacology
Time Factors
Grant Support
ID/Acronym/Agency:
EY 03702/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Arachidonic Acids; 0/Prostaglandins; 0/Pyrazoles; 0/Saline Solution, Hypertonic; 506-32-1/Arachidonic Acid; 53-86-1/Indomethacin; 92-43-3/phenidone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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